Protein-specific turnover in the human brain; Measuring protein-specific synthesis rates of the human brain using the D2O dosing method

Completed

• Conditions: Brain diseases; Temporal Lobe Surgery; 10028393; 10029305

• Registration Number: NL-OMON55574
• Lead Sponsor: niversiteit Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 12

Inclusion Criteria

* Written informed consent
* Male and female patients scheduled for temporal lobectomy
* Age 18 - 65 years
* Compos mentis

Exclusion Criteria

* Comorbidities and neuromuscular disorders of the lower limbs severely
interacting with mobility, with limited or no opportunity for improvement (e.g.
cerebral palsy)
* Peripheral artery disease Fontaine III or IV
* Chronic Obstructive Pulmonary Disease (COPD) GOLD III or IV
* Use of systemic steroids in the past four weeks, other than indicated for the
specific type of surgery
* Use of anti-inflammatory biologicals (e.g. TNF-alfa blockers) in the past
four weeks
* Surgical intervention in the past four weeks
* Total parenteral nutrition at day of surgery
* Pregnancy
* Neoadjuvant chemotherapy or radiotherapy

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Primary study parameters include protein synthesis rates and enrichments of<br /><br>neocortex, hippocampus, temporalis muscle, and vastus lateralis muscle. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary parameters include whole-body protein synthesis, breakdown,<br /><br>oxidation, and net balance. </p><br>