Unknown Glucose Metabolism Disorders In Patients With Coronary Artery Disease

Completed

• Conditions: Diabetes Mellitus
• Interventions: Other: ogtt for patients with coronary artery disease

• Registration Number: NCT01310556
• Lead Sponsor: Gulhane School of Medicine

Brief Summary

This study aimed to examine the prevalence of glucose metabolism disorders (GMD)in the patients with coronary artery disease and the relationship between different GMDs and coronary artery disease (CAD).

Detailed Description

Context: There are more than 220 million people diagnosed with diabetes mellitus (DM) in the world. DM is a serious risk factor for coronary artery disease (CAD). This study aimed to examine the prevalence of glucose metabolism disorders (GMD) in te patients with coronary artery disease and the relationship between different GMDs and CAD.

Settings: 230 patients with coronary artery disease and without any known GMDs were included the study. Coronary angiography was used to diagnose CAD. Patients were administered the 75 g Oral Glucose Tolerance Test (OGTT).

Study Timeline

• Status Verified: 2009-06
• Study Start: 2009-06
• Primary Completion: 2010-06
• Study Completion: 2010-06
• Study First Submitted: 2011-03-07
• Study First Submitted QC: 2011-03-07
• Study First Posted: 2011-03-08
• Last Update Submitted: 2011-06-17
• Last Update Posted: 2011-06-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 230

Inclusion Criteria

• Patients with coronary artery disease and who had no glucose metabolism disorders were included to study.

Exclusion Criteria

• Patients who had previous GMDs, malignancies, chronic liver and kidney diseases, rheumatologic disorders, and a BMI higher than 35 kg/m2 were excluded from the study.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
coronary artery disease	ogtt for patients with coronary artery disease	patients with coronary artery disease

Primary Outcome Measures

Name	Time	Method
Frequency of unknown glucose metabolism disorders in patients with coronary artery disease	1 year	Results: While GMDs were detected in 58.26% (n=134 patients) of CAD patients, 41.74% of them (n=96 patients) were found to have normal glucose metabolism.

Secondary Outcome Measures

Name	Time	Method
Fasting and 120 minute glucose levels have relation with vessels' stenosis.	1 year	Fasting glucose level was found to have a significant correlation with the total number of stenotic coronary vessels (p=0.0001) and the stenosis rate of all vessels . OGTT 120-minute glucose levels were found to have a significant correlation with the total number of stenotic coronary vessels and the stenosis rate of vessels with the exception of LAD.

Trial Locations

Locations (1)

Gulhane School of Medicine; 🇹🇷 Ankara, Turkey