ACTRN12617000395336已完成4 期
Targeting neutrophil extracellular traps with dornase alfa to reduce inflammation in chronic airway disease
niversity of Newcastle0 个研究点目标入组 30 人开始时间: 2017年3月17日最近更新:
适应症
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 30
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomised controlled trial
- 主要目的
- Treatment
- 盲法
- Blinded (masking used)
入排标准
- 年龄范围
- 18 Years 至 o limit（—）
- 性别
- All
入选标准
- •Males and females aged >18 years with Doctor diagnosed stable COPD, confirmed by incompletely reversible airflow obstruction (post bronchodilator FEV1<80% predicted and FEV1/FVC<70%)
- •Males and females aged >18 years with Doctor diagnosed stable asthma
- •Non-smokers or ex-smokers (> 6 months since last cigarette).
- •High levels of sputum NETs (>20ng/uL eDNA, conducted in Aim 1) (determined after screening visit)
排除标准
- •COPD or asthma exacerbation or respiratory tract infection (OCS or antibiotics), or change in maintenance therapy in the past 6 weeks (visit will be postponed)
- •Current smoking (last 6 months)
- •Any use of antibiotics in the past month (visit will be postponed)
- •Pregnancy or breastfeeding
- •Inability to attend clinic visits
- •Other significant illness likely to interfere with management or participation in the study
- •Participation in any other interventional research study in the last 4 weeks
研究者
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