Feasibility and Efficacy of a High-Intensity Exercise Intervention in Elderly Healthy Controls
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Functional Fitness
- Sponsor
- University of California, Berkeley
- Enrollment
- 4
- Locations
- 1
- Primary Endpoint
- Number of Repetitions in 30-Second Chair Stand Test
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
The goal of this interventional study was to test the high-intensity interval training called Aphasia Physical Exercise (APEX) in healthy older adults. The main questions it aimed to answer were:
- what is the safety and feasibility of APEX?
- what are APEX's acute physiological effects?
- what is APEX's effects on functional fitness?
- what is APEX's effects on cognition?
Participants underwent:
- Baseline testing session (#1) with cognitive measures only (a week before the Pre-exercise session);
- Pre-exercise session (#2) with maximum oxygen consumption and heart rate assessment, functional fitness and cognitive measures (3-7 days before the start of the exercise program);
- APEX program, two APEX classes per week for four weeks (eight classes in total);
- Post-exercise session (#3), functional fitness and cognitive measures, (0-2 days after the end of the exercise program).
Investigators
Maria Ivanova
Research Scientist
University of California, Berkeley
Eligibility Criteria
Inclusion Criteria
- •Between the ages of 50 and 80
- •Ambulatory and community-dwelling
- •Able to travel to University of San Francisco for weekly exercise classes
- •No serious underlying health or neurological conditions
Exclusion Criteria
- •Inability to complete physical function assessment or inability to do a chair stand without using hands
- •Use of antidiabetic medications
- •Use of testosterone supplement or replacement
- •Clinical disorder precluding/interfering with participation or assessments (identified by Physical Activity Readiness Questionnaire (PAR-Q+)), including: unstable angina, arrhythmia, uncontrolled hypertension, end stage renal disease on hemodialysis, lower extremity amputation or paralysis, neurological conditions causing functional or pronounced cognitive impairments, active malignancy except for non-melanomatous skin cancers
- •Previous neurological history such as stroke, traumatic brain injury, multiple sclerosis, long-term pre-stroke seizures, Parkinson's, Alzheimer's, etc.
- •Unable to provide consent
Outcomes
Primary Outcomes
Number of Repetitions in 30-Second Chair Stand Test
Time Frame: Once 3-7 days before start of intervention and once 0-2 days after end of intervention
The number of sit-to-stands completed in 30 seconds on a standard 17" seat-height chair with arms folded across the chest.
Visual Search Task Reaction Time
Time Frame: Once 10-14 days before start of intervention, once 3-7 days before start of intervention, and once 0-2 days after end of intervention
Reaction time on correct trials in seconds
Forward Digit Span
Time Frame: Once 10-14 days before start of intervention, once 3-7 days before start of intervention, and once 0-2 days after end of intervention
The length of the longest sequence of random digits that a participant can correctly recall twice.
Heart Rate
Time Frame: 4 weeks during intervention
Heart rate measured in beats per minute.
Functional Reach Test Distance
Time Frame: Once 3-7 days before start of intervention and once 0-2 days after end of intervention
The distance in inches of an individual's forward reach with one arm while maintaining a standing position with feet flat on the floor at hip width.
Attendance Rate
Time Frame: 4 weeks during intervention
The number of classes attended out of eight total classes.
Timed Up-And-Go Time
Time Frame: Once 3-7 days before start of intervention and once 0-2 days after end of intervention
The number of seconds for an individual to rise from a seated position, walk eight feet, turn around, and return to a seated position.
Number of Steps in 2-minute Step Test
Time Frame: Once 3-7 days before start of intervention and once 0-2 days after end of intervention
The number of right knee raises completed in two minutes while marching in place and raising each knee to a point midway between the patella (kneecap) and iliac crest (top hip bone).
Forward Spatial Span
Time Frame: Once 10-14 days before start of intervention, once 3-7 days before start of intervention, and once 0-2 days after end of intervention
The length of the longest sequence of random positions that a participant can correctly recall.
Backward Spatial Span
Time Frame: Once 10-14 days before start of intervention, once 3-7 days before start of intervention, and once 0-2 days after end of intervention
The length of the longest sequence of random positions that a participant can correctly report backward.
Go/No-Go Task Hits
Time Frame: Once 10-14 days before start of intervention, once 3-7 days before start of intervention, and once 0-2 days after end of intervention
Hits are the proportion of correct responses on trials when "go" is presented.
Flanker Task Reaction Times
Time Frame: Once 10-14 days before start of intervention, once 3-7 days before start of intervention, and once 0-2 days after end of intervention
Reaction time on correct trials in seconds.
Stroop Task Accuracy
Time Frame: Once 10-14 days before start of intervention, once 3-7 days before start of intervention, and once 0-2 days after end of intervention
Number of correct trials.
Stroop Task Reaction Times
Time Frame: Once 10-14 days before start of intervention, once 3-7 days before start of intervention, and once 0-2 days after end of intervention
Reaction time on correct trials in seconds.
Visual Search Task Accuracy
Time Frame: Once 10-14 days before start of intervention, once 3-7 days before start of intervention, and once 0-2 days after end of intervention
Number of correct trials
Backward Digit Span
Time Frame: Once 10-14 days before start of intervention, once 3-7 days before start of intervention, and once 0-2 days after end of intervention
The length of the longest sequence of random digits that a participant can correctly report backward twice.
Flanker Task Accuracy
Time Frame: Once 10-14 days before start of intervention, once 3-7 days before start of intervention, and once 0-2 days after end of intervention
Number of correct trials.
Go/No-Go Task Reaction Times
Time Frame: Once 10-14 days before start of intervention, once 3-7 days before start of intervention, and once 0-2 days after end of intervention
Reaction times are for hit trials only (correct responses when "go" is presented) in seconds.