The Second Affiliated Hospital of Nanchang University
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Postoperative Delirium
- Sponsor
- Second Affiliated Hospital of Nanchang University
- Enrollment
- 334
- Locations
- 1
- Primary Endpoint
- Incidence of postoperative delirium
- Status
- Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
The goal of this observational study is to compare Incidence of postoperative delirium in Sarcopenic and non-sarcopenic elderly patients undergoing gastrointestinal surgery. The main question it aims to answer are:
• Effect of preoperative sarcopenia on postoperative delirium in elderly patients undergoing gastrointestinal surgery Participants will be evaluated preoperatively for sarcopenia and assessed for postoperative delirium, pain, etc.
Investigators
Fuzhou Hua
Chief Physician
Second Affiliated Hospital of Nanchang University
Eligibility Criteria
Inclusion Criteria
- •Age ≥ 65 years old, gender is not limited
- •Patients to undergo elective abdominal surgery (gastrointestinal tumor resection) under general anesthesia, with an expected operation duration of about 2h\~4h
Exclusion Criteria
- •Relative contraindications to general anesthesia: Patients with severe heart and lung disease, severe infection, uncontrolled hypertension, diabetes, and severe diabetic complications
- •Abnormal renal and liver function: AST or ALT≥2.5×ULN, TBIL≥1.5×ULN, Serum creatinine concentration (SCC)≥1.5×ULN
- •People with a history of mental illness or long-term use of psychotropic drugs (dementia, schizophrenia), chronic analgesic drug use, alcoholism, and cognitive impairment
- •Any cardiovascular or cerebrovascular accidents occurred within 3 months, such as myocardial infarction, stroke, transient ischemic attack
- •Myasthenia gravis patients
- •Unable to cooperate to complete the test, the patient or family member rejected the participant
Outcomes
Primary Outcomes
Incidence of postoperative delirium
Time Frame: Within 7 days after surgery. Delirium at any time during the 7 days after surgery was considered postoperative delirium.
Postoperative delirium was assessed using the 3D-CAM scale. It consists of 4 features, and a positive feature 1 and 2 plus 3 or 4 is considered postoperative delirium.
Secondary Outcomes
- Diastolic pressure(Up to 5 hours in the operating room)
- Postoperative pain(Within 7 days after surgery)
- Minimum postoperative albumin(Up to 1 month after surgery)
- Systolic pressure(Up to 5 hours in the operating room)
- Mean pressure(Up to 5 hours in the operating room)
- Complication(During the perioperative period, up to 1 month after surgery)
- Length of stay in ICU(Up to 1 month after surgery)
- Maximum postoperative C-reactive protein (CRP)(Up to 1 month after surgery)
- Heart rate(Up to 5 hours in the operating room)
- Incidence of postoperative admission to ICU(Up to 1 month after surgery)
- Length of hospitalization(After the patient is discharged from the hospital, average 1 month)