Non-contact DCS-Speckle Multi-parameter Imaging for Neurological Diseases

• Conditions: Optical Imaging; Brain Edema; Brain Injuries
• Interventions: Diagnostic Test: Non-contact DCS-Speckle multi-parameter imaging

• Registration Number: NCT04623307
• Lead Sponsor: Ting Li

Brief Summary

This study aims to evaluate brain injuries and brain edema with non-contact DCS-Speckle multi-parameter imager.

Detailed Description

Brain injuries includes acute and chronic injuries located in cerebral hemispheres, cerebellum, and brain stem, while brain edema is increased intracellular or extracellular fluid in brain tissue. Early diagnosis is helpful to improve the cure rate and reduce sequelae. This study aims to evaluate brain injuries and brain edema with non-contact DCS-Speckle multi-parameter imager, so as to provide reference diagnostic criteria by image artificial intelligence analysis.

Study Timeline

• Status Verified: 2020-11
• Study Start: 2020-11-01
• Study First Submitted: 2020-11-09
• Study First Submitted QC: 2020-11-09
• Last Update Submitted: 2020-11-09
• Study First Posted: 2020-11-10
• Last Update Posted: 2020-11-10
• Primary Completion: 2021-10-31
• Study Completion: 2021-12-31

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Patients who have had brain damage.
• Patients who have had brain edema.
• Healthy people who are interested in non-contact DCS-Speckle multi-parameter imaging

Exclusion Criteria

• Patients who are in pregnancy or have plan to conception.
• Patients who have vertebra surgery or have plan to surgery.
• Patients who are inappropriate to join this trial judged by the radiologists or specialists.
• AIDS, Active Hepatitis, Tuberculosis, Syphilis
• Patients who regularly take anticoagulants, antiplatelet drugs

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Brain damage patients	Non-contact DCS-Speckle multi-parameter imaging	Brain damage patients were monitored the human brain activity by the non-contact DCS-Speckle multi-parameter imager.
Brain edema patients	Non-contact DCS-Speckle multi-parameter imaging	Brain edema patients were monitored the human brain activity by the non-contact DCS-Speckle multi-parameter imager.
Healthy subjects	Non-contact DCS-Speckle multi-parameter imaging	Healthy subjects were monitored the human brain activity by the non-contact DCS-Speckle multi-parameter imager.

Primary Outcome Measures

Name	Time	Method
Imaging data	1 day during the whole experiment	Imaging data collected during the non-contact DCS-Speckle imaging instrument

Secondary Outcome Measures

Name	Time	Method
Diagnostic report fMRI data	1 day during the whole experiment	Patients' medical record and diagnostic report

Trial Locations

Locations (1)

NIRS assessment for brain death; 🇨🇳 Tianjin, Tianjin, China