A Study of Guselkumab and Interleukin-17 (IL-17) Inhibitor Therapies in Participants With Psoriatic Arthritis in Routine Clinical Practice
- Registration Number
- NCT05049798
- Lead Sponsor
- Janssen Pharmaceutica N.V., Belgium
- Brief Summary
The purpose of this study is to evaluate treatment persistence with guselkumab and interleukin-17 inhibitor (IL-17i) initiated at enrollment into this study (PsABIOnd).
- Detailed Description
Psoriatic arthritis (PsA) is a seronegative inflammatory spondylarthritis associated with psoriasis (PsO), which can cause pain and swelling in the joints, sausage-shaped swelling of the fingers and toes (dactylitis), inflammation of the muscle- or tendon insertions at adjacent bone (enthesitis), as well as raised red patches or various other expressions of psoriasis on the skin. Guselkumab (TREMFYA) is a fully human immunoglobulin G1 lambda (IgG1) monoclonal antibody (mAb) that binds to the p19 subunit of human interleukin (IL) 23 with high specificity and affinity, blocking IL-23 binding. Binding of guselkumab to the IL-23p19 subunit blocks the subsequent binding of extracellular IL-23 to the cell surface IL-23 receptor, inhibiting IL-23 specific intracellular signaling and subsequent activation and cytokine production. Participants with confirmed diagnosis of PsA who are starting guselkumab or any marketed interleukin-17 inhibitor (IL-17i) as a first, second, third, or fourth line of PsA biologic therapy per standard clinical practice will be enrolled in the main study. The aim of main study is to document the use of guselkumab and approved IL-17i therapies in routine clinical practice in patients with PsA who are starting guselkumab or an IL-17i as a first, second, third, or fourth line of biologic disease-modifying antirheumatic drugs (bDMARD) therapy. The overall duration of the main study, including recruitment and follow-up, is expected to be about 6 years. Participants who are starting guselkumab or an IL-17i treatment per routine clinical practice in the main study, and who meet the selection criteria for both the main study and substudy, will be consecutively offered entry into the substudy (a select number) at the time of enrollment into the main study. The substudy aims to collect additional data, continuously or with increased frequency, on the impact of guselkumab or IL-17i on patient mood, physical activity, sleep disturbance, disease symptoms, and health-related quality-of-life (HRQoL). Total duration of the substudy will be approximately 26-30 weeks consisting of a pre-treatment period of up to 14 days before the first dose of guselkumab or IL-17i in the main study and a 24-week (plus \[+\] up to 4 weeks follow-up) observation period.
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 1314
Main study:
- Have a confirmed diagnosis of PsA as determined by a rheumatologist with reference to Classification criteria for Psoriatic Arthritis (CASPAR)
- Start guselkumab or any approved interleukin-17 inhibitor (IL-17i) as a first, second, third, or fourth line of biologic disease-modifying antirheumatic drugs (bDMARD) therapy for the indication of PsA as part of standard clinical practice (according to local label, local regulations, and/or reimbursement requirements) at the time of enrollment into the observational study or within a maximum of 2 months after the initial baseline visit or after repeated baseline data collection
- Sign a participation agreement/Informed consent form (ICF) allowing data collection and source data verification in accordance with local requirements
- Able to read, understand, and intend to comply with completion of all Electronic patient-reported outcome (ePRO) instruments
- The treatment decision must be taken by the participating rheumatologist prior to, and independently of the participant's inclusion into the study, following clinical practice in accordance with local and overarching guidelines and local regulations
Substudy:
- Must sign the substudy ICF allowing data collection in accordance with local requirements
- Is scheduled to receive guselkumab or IL-17i, per routine clinical practice, in the main study
- Currently using or is willing to use wearables and/or commercial applications to track their disease within the course of their normal daily activities
Main study:
- Start guselkumab or an IL-17i therapy as fifth or further line of biologic treatment
- Have already taken a specific IL-17i or IL-23i treatment and are planning on re-taking that specific treatment again
- Unwilling or unable to participate in long-term data collection
- Received an investigational drug (including investigational vaccines) or used an invasive investigational medical device within 30 days before the start of the study (that is, signing of informed consent)
- Currently enrolled in any interventional study or any Janssen-sponsored observational clinical study (contemporary participation into observational studies or registries not sponsored by Janssen is acceptable)
Substudy:
- Have an insufficient command of language to interact effectively with the smartphone application, in the opinion of the investigator at each site
- Any condition for which, in the opinion of the investigator, participation would not be in the best interest of the patient (example, compromise the well-being) or that could prevent, limit, or confound assessment
- Unwilling or unable to comply with substudy assessments
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Cohort 1: Guselkumab Guselkumab Data as available from participant's source medical records will be collected for adult participants with a confirmed diagnosis of Psoriatic Arthritis (PsA) who are starting guselkumab as a first, second, third, or fourth line of PsA biologic therapy either as monotherapy or with other medications per routine clinical practice in main study. Participants who meet the selection criteria for both the main study and substudy, will be consecutively offered to be enrolled into the substudy at the time of enrollment into the main study. Cohort 2: Interleukin-17 inhibitor (IL-17i) IL-17i Data as available from participant's source medical records will be collected for adult participants with a confirmed diagnosis of PsA who are starting IL-17i as a first, second, third, or fourth line of PsA biologic therapy either as monotherapy or with other medications per routine clinical practice in main study. Participants who meet the selection criteria for both the main study and substudy, will be consecutively offered to be enrolled into the substudy at the time of enrollment into the main study.
- Primary Outcome Measures
Name Time Method The Start and Stop Date of Guselkumab, as Applicable, For Each Participant Up to 39 months The start and stop date, (first and last administration date, respectively) of guselkumab, as applicable, for each participant will be collected to document treatment persistence.
The Start and Stop Date of Interleukin-17 Inhibitor (IL-17i), as Applicable, For Each Participant Up to 39 months The start and stop date (first and last administration date respectively) of IL-17i, as applicable, for each participant will be collected to document treatment persistence.
- Secondary Outcome Measures
Name Time Method Change from Baseline in 66 and 68 Joint Counts for Swelling and Tenderness, Respectively Baseline up to 39 months Change from baseline in 66 and 68 joint counts for swelling and tenderness, respectively will be reported. Joints assessed include the distal interphalangeal, proximal interphalangeal, and metacarpophalangeal joints of the hands; the wrist, elbow, shoulder, acromioclavicular, sternoclavicular, temporomandibular, hip (excluded for swelling), knee, ankle, and midtarsal joints; and the metatarsophalangeal and proximal interphalangeal joints of the feet.
Change from Baseline in Assessment of Dactylitis Baseline up to 39 months The presence of and total number of digits of the hands and feet (that is, 0 to 20) with dactylitis will be documented.
Change from Baseline in Rheumatologist's Global Assessment of Disease Activity-Psoriatic Arthritis (PGA-PsA) Baseline up to 39 months The PGA-PsA will be documented using a Visual Analogue Scale (VAS) that ranges from "no PsA activity" (0 Millimeter \[mm\]) to "extremely active PsA" (100 mm).
Change from Baseline in Assessment of Enthesitis using Leeds Enthesitis Index (LEI) Baseline up to 39 months The presence and a score of enthesitis will be documented using the LEI to evaluate the presence (score of 1) or absence (score of 0) of pain by applying local pressure to the following entheses: the lateral epicondyles (left and right), medial femoral condyles (left and right), and Achilles tendon insertions (left and right).
Change from Baseline in Psoriatic Arthritis Impact of Disease-12 (PsAID-12) Baseline up to 39 months PsAID-12 is a validated, self-administered questionnaire that assesses the impact of PsA on participants' lives. It consists of 12 questions, each answered using a numerical rating scale. Questions related to pain, skin problems, work and/or leisure activities, discomfort, embarrassment and/or shame, social participation, and anger, fear, and uncertainty, and depression are scored from 0 (none) to 10 (extreme), functional capacity and sleep disturbance are scored from 0 (no difficulty) to 10 (extreme difficulty) and coping is scored from 0 (very well) to 10 (very poorly).
Change from Baseline in Patient Global Disease Activity Visual Analog Scale (VAS) Scores Baseline up to 39 months The Patient Global Disease Activity VAS is a self-administered assessment with scores ranging from "very well" (0 mm) to "very poor" (100 mm) that assesses disease activity over the past week.
Change from Baseline in Pain VAS Score Baseline up to 39 months The pain VAS is a self-administered assessment of average pain during the past week. The scale ranges from "no pain" (0 mm) to "the worst possible pain" (100 mm).
Change from Baseline in Dermatology Life Quality Index (DLQI) Baseline up to 39 months The DLQI is a dermatology-specific, validated, 10-question quality of life instrument used to measure the impact of skin disease on the quality of life of an affected person. Each question will address how much the participant's skin problem has affected their life and is scored as: 3 = very much, 2 = a lot, 1 = a little, 0 = not at all, or not relevant.
Change from Baseline in Patient Acceptable Symptom State (PASS) Baseline up to 39 months The PASS measures the level of symptoms beyond which participants consider themselves well. The PASS addresses the concepts of low disease activity, partial remission in symptoms, and well-being.
Change from Baseline in Clinical Disease Activity Index for Psoriatic Arthritis (cDAPSA/DAPSA) Baseline up to 39 months DAPSA assesses the joint domain of PsA and is derived from the sum of the following components: Participant's assessment of pain on VAS (in centimeters), Participant's Global Assessment of Disease Activity on VAS (in centimeters), 66 and 68 joint counts for swelling and tenderness, respectively.
Response as a Measure of Clinical Improvement in cDAPSA/DAPSA Up to 39 months Response is defined as a clinical improvement in cDAPSA/DAPSA. DAPSA assesses the joint domain of PsA and is derived from the sum of the following components: Participant's assessment of pain on VAS (in centimeters), Participant's Global Assessment of Disease Activity on VAS (in centimeters), 66 and 68 joint counts for swelling and tenderness, respectively.
Start and Stop Dates of All Treatments and the Sequence of Treatment Lines Up to 39 months Start and stop dates of all treatments and the sequence of treatment lines will be reported.
Rheumatic Disease Comorbidity Index Up to 39 months Number of comorbid medical conditions of the study participants for the Rheumatic Disease Comorbidity Index will be reported.
Change from Baseline in Work Productivity and Activity Impairment Questionnaire: Psoriatic Arthritis (WPAI: PsA) Baseline up to 39 months The WPAI: PsA is a validated, self-administered questionnaire that assesses work and activity impairment during the past 7 days. The WPAI: PsA produces 4 types of scores: absenteeism (work time missed), presenteeism (impairment at work/reduced on-the-job effectiveness), work productivity loss (overall work impairment/absenteeism plus presenteeism), and activity impairment. The WPAI: PsA outcomes are expressed as impairment percentages, with higher numbers indicating greater impairment and less productivity, that is, worse outcomes.
Number of Participants Switching or Stopping Treatment Up to 39 months Number of Participants switching or stopping treatment (including reasons for discontinuation) will be reported.
Change from Baseline in Nail Involvement Baseline up to 39 months Nail involvement will be documented by recording the total number of nails of the hands and feet (that is, 0 to 20) with psoriatic nail changes.
Change from Baseline in Body Surface Area (BSA) Psoriasis (PSO) Skin Involvement Baseline up to 39 months The BSA score indicates the surface area of the participant's body effected by psoriasis.
Change from Baseline in Minimal Disease Activity (MDA)/ Very Low Disease Activity (VLDA) Baseline up to 39 months Change from Baseline in MDA/VLDA will be reported.
Percentage of Participants with Adverse Events (AEs) Up to 39 months An AE is any untoward medical occurrence in a participant participating in a clinical study that does not necessarily have a causal relationship with the pharmaceutical/biological agent under study.
BSA PSO Skin Involvement Up to 39 months The BSA score indicates the surface area of the participant's body affected by psoriasis.
Change from Baseline in Fibromyalgia Rapid Screening Tool (FiRST) Baseline up to 6 months FiRST will be used to help determine whether participants have chronic widespread pain or fibromyalgia syndrome at entry into the study. The FiRST is a validated questionnaire consisting of a combination of 6 items that can detect chronic widespread pain.
Change from Baseline in C-reactive Protein (CRP) Baseline up to 39 months Change from baseline in CRP will be reported.
Change from Baseline in European Quality of Life (EuroQoL) 5-Dimensions 5-Levels Questionnaire (EQ-5D-5L) Baseline up to 39 months The EQ-5D-5L is a standardized instrument for use as a measure of health outcome, primarily designed for self-completion by respondents. The EQ-5D-5L descriptive system comprises the following 5 dimensions: mobility, self-care, usual activities, pain/discomfort and anxiety/depression. Each of the 5 dimensions is divided into 5 levels of perceived problems, where Level 1: no problem, Level 2: slight problems, Level 3: moderate problems, Level 4: severe problems and Level 5: extreme problems.
Change from Baseline in Health Assessment Questionnaire-Disability Index (HAQ-DI) Baseline up to 39 months The functional status of the participants will be assessed by the HAQ-DI. This 20-question self-administered instrument assesses the degree of difficulty a person has in accomplishing tasks in 8 functional areas (dressing, arising, eating, walking, hygiene, reaching, gripping, and activities of daily living). The derived HAQ-DI ranges from 0, indicating no difficulty, to 3, indicating inability to perform a task in that area.
Change from Baseline in Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) Baseline up to 39 months BASDAI consists of a 1 through 10 scale (1 being no problem and 10 being the worst problem) which is used to answer 6 questions pertaining to the 5 major symptoms of ankylosing spondylitis: fatigue, spinal pain, joint pain/swelling, areas of localized tenderness (also called enthesitis, or inflammation of tendons and ligaments), morning stiffness duration, morning stiffness severity.
Change from Baseline in Ankylosing Spondylitis Disease Activity Score - C-reactive protein (ASDAS-CRP) Baseline up to 39 months The ASDAS-CRP is a composite of 5 disease activity variables with only partial overlap. The 4 self-reported items included in this index are back pain (VAS), duration of morning stiffness, peripheral pain/swelling, and participant global assessment of disease activity; these are combined with the CRP value.
Change from Baseline in Treatment Satisfaction Questionnaire for Medication-9 (TSQM-9) Baseline up to 39 months TSQM-9 is a 9-item, validated, self-administered instrument used to assess participant's satisfaction with medication. The three domains assessed are effectiveness, convenience, and side effects of the medication.
Trial Locations
- Locations (153)
Universitatsklinikum Frankfurt
🇩🇪Frankfurt, Germany
Rheumapraxis Dr. Liebhaber
🇩🇪Halle-Saale, Germany
Hosp. Univ. Central de Asturias
🇪🇸Oviedo, Spain
Hospital J. M. Ramos MejÃa
🇦🇷Buenos Aires, Argentina
Manitoba Clinic
🇨🇦Winnipeg, Manitoba, Canada
Private Practice - Dr. Pauline Boulos
🇨🇦Dundas, Ontario, Canada
Markham Rheumatology Hub
🇨🇦Markham, Ontario, Canada
CHRU HOPITAL ROGER SALENGRO Consultation Appareil locomoteur
🇫🇷Lille, France
Centre Orthopedique Santy
🇫🇷Lyon, France
Clinique de l'Infirmerie Protestante de Lyon
🇫🇷Lyon, France
Hôpital Saint Roch
🇫🇷Nice, France
CHR Orléans - Nouvel Hôpital Orléans La Source
🇫🇷Orléans, France
Hôpital Lariboisière - Centre Viggo Petersen
🇫🇷Paris, France
Hopital Saint-Antoine
🇫🇷Paris, France
Hôpital Bichat
🇫🇷Paris, France
Hôpital Pitié-Salpétrière
🇫🇷Paris, France
CHRU Hôpital de Hautepierre
🇫🇷Strasbourg Cedex, France
Hopital Purpan
🇫🇷Toulouse, France
Praxis für Rheumatologie
🇩🇪Amberg, Germany
Rheuma-Praxis Bayreuth
🇩🇪Bayreuth, Germany
Rheumatologische Schwerpunktpraxis
🇩🇪Berlin, Germany
Universitatsklinikum Dusseldorf
🇩🇪Dusseldorf, Germany
Service Rheuma Erfurt
🇩🇪Erfurt, Germany
Centre Hospitalier Universitaire(CHU) - Hopital Henri Mondor
🇫🇷Creteil, France
Azienda Ospedaliero Universitaria S.Maria Della Misericordia
🇮🇹Udine, Italy
Hôpital Gabriel Montpied
🇫🇷Clermont Ferrand, France
CHU Grenoble
🇫🇷Echirolles, France
Hosp. Univ. de Getafe
🇪🇸Madrid, Spain
Hospital Italiano de Buenos Aires
🇦🇷Buenos Aires, Argentina
OMI
🇦🇷Ciudad Autónoma de Buenos Aires, Argentina
Hospital Cordoba
🇦🇷Córdoba, Argentina
MR Medicina Reumatologica
🇦🇷San Fernando, Argentina
The Queen Elizabeth Hospital
🇦🇺Adelaide, Australia
Footscray Hospital, Western Health
🇦🇺Footscray, Australia
Royal North Shore Hospital
🇦🇺St Leonards, Australia
LKH-Univ. Klinikum Graz
🇦🇹Graz, Austria
Kepler Universitatsklinikum GmbH
🇦🇹Linz, Austria
Medizinische Universitaet Wien
🇦🇹Vienna, Austria
Evang. Krankenhaus Gemein. Betriebgesm. Mbh
🇦🇹Wien, Austria
AZ Sint-Jan
🇧🇪Brugge, Belgium
Hopital Erasme
🇧🇪Brussel, Belgium
Reumaclinic Genk-Hasselt
🇧🇪Genk, Belgium
UZ Leuven
🇧🇪Leuven, Belgium
CHU de Liège - Domaine Universitaire du Sart Tilman
🇧🇪Liège, Belgium
Artus Health Centre
🇨🇦Vancouver, British Columbia, Canada
Riverside Professional Centre
🇨🇦Sydney, Nova Scotia, Canada
Brandusa Florica Medicine Professional Corporation
🇨🇦Mississauga, Ontario, Canada
The Waterside Clinic
🇨🇦Orillia, Ontario, Canada
The Ottawa Hospital Research Institute
🇨🇦Ottawa, Ontario, Canada
Dr. Sabeen Anwar Medicine Professional Corporation
🇨🇦Windsor, Ontario, Canada
CIUSSS de l Est de l Ile de Montreal Installation Hopital Maisonneuve Rosemont
🇨🇦Montreal, Quebec, Canada
Centre de sante et services sociaux (CSSS) de Rimouski-Neigette - Hopital regional - Rimouski
🇨🇦Rimouski, Quebec, Canada
Centre Hospitalier Universitaire de Sherbrooke
🇨🇦Sherbrooke, Quebec, Canada
Centre de Recherche Musculo Squelettique
🇨🇦Trois Rivieres, Quebec, Canada
Community Rheumatology Care
🇨🇦Saskatoon, Saskatchewan, Canada
Rheumatology Associates of Saskatoon
🇨🇦Saskatoon, Saskatchewan, Canada
G R M O Groupe de recherche en maladies osseuses Inc
🇨🇦Quebec, Canada
BIOMAB
🇨🇴Bogota, Colombia
Servimed S A S
🇨🇴Bucaramanga, Colombia
Clinica Vascular las Americas
🇨🇴Medellin, Colombia
Clinisalud del Sur
🇨🇴MedellÃn, Colombia
Funcentra
🇨🇴MonterÃa, Colombia
Hôpital Avicenne
🇫🇷Bobigny, France
Centre Hospitalier de Cholet
🇫🇷Cholet, France
Praxis fur Klinische Studien und Praxis fur Orthopadie
🇩🇪Hamburg, Germany
Rheumatologie im Struenseehaus
🇩🇪Hamburg, Germany
Rheumazentrum Ruhrgebiet
🇩🇪Herne, Germany
Krankenhaus Porz am Rhein
🇩🇪Koln, Germany
Rheumatologische Praxis
🇩🇪Magdeburg, Germany
Praxiszentrum St. Bonifatius
🇩🇪München, Germany
Praxis Thilo Klopsch
🇩🇪Neubrandenburg, Germany
Knappschaftsklinikum Saar GmbH Klinik für Rheumatologie
🇩🇪Püttlingen, Germany
Rheumazentrum Ratingen
🇩🇪Ratingen, Germany
Rheumatologisch-immunologische Arztpraxis
🇩🇪Templin, Germany
Immunologisches Zentrum Vogelsang-Gommern GmbH
🇩🇪Vogelsang-Gommern, Germany
Evangelismos General Hospital of Athens
🇬🇷Athens, Greece
Athens Navy Hospital
🇬🇷Athens, Greece
General Hospital 'Gennimatas'
🇬🇷Athens, Greece
Hippokration General Hospital of Athens, B' Internal Medicine Clinic,
🇬🇷Athens, Greece
Laiko General Hospital of Athens
🇬🇷Athens, Greece
University Hospital of Ioannina
🇬🇷Ioannina, Greece
University General Hospital of Rio Patras
🇬🇷Patras, Greece
'Agios Andreas' General Hospital of Patras
🇬🇷Patra, Greece
Ippokrateio Hospital
🇬🇷Thessaloniki, Greece
Azienda Ospedaliero Universitaria Consorziale Policlinico di Bari
🇮🇹Bari, Italy
Ospedale Regionale Cardarelli-Università degli Studi del Mol
🇮🇹Campobasso, Italy
Universita della Magna grecia
🇮🇹Catanzaro, Italy
AOU Careggi
🇮🇹Firenze, Italy
Azienda Ospedaliera Universitaria Federico II
🇮🇹Napoli, Italy
Seconda Univesità degli Studi di Napoli, AOU
🇮🇹Napoli, Italy
Azienda Ospedaliero Universitaria Policlinico Paolo Giaccone
🇮🇹Palermo, Italy
Azienda Ospedaliero Universitaria Pisana
🇮🇹Pisa, Italy
Ospedale San Carlo Di Potenza - Azienda Ospedaliera Regionale
🇮🇹Potenza, Italy
Universita Cattolica del Sacro Cuore
🇮🇹Rome, Italy
Istituto Clinico Humanitas
🇮🇹Rozzano, Italy
Azienda Ospedaliera Città della Salute e della Scienza di Torino
🇮🇹Torino, Italy
Azienda Ospedaliera Universitaria Integrata Verona
🇮🇹Verona, Italy
Kita-harima Medical Center
🇯🇵Hyogo, Japan
Toho University Medical Center, Ohashi Hospital
🇯🇵Meguro-ku, Japan
Osaka Metropolitan University Hospital
🇯🇵Osaka, Japan
Public Interest Incorporated Foundation Nipoon Life Saiseikai Nippon Life Hospital
🇯🇵Osaka, Japan
Hokkaido University Hospital
🇯🇵Sapporo, Japan
Kyorin University Hospital
🇯🇵Tokyo, Japan
Soonchunhyang University Cheonan Hospital
🇰🇷Cheonan-si, Korea, Republic of
Seoul National University Bundang Hospital
🇰🇷Seongnam, Korea, Republic of
Seoul National University Hospital
🇰🇷Seoul, Korea, Republic of
Seoul Metropolitan Government Seoul National University Boramae Medical Center
🇰🇷Seoul, Korea, Republic of
Medical Care & Research SA de CV
🇲🇽Merida, Mexico
Consultorio de Reumatologia
🇲🇽Mexico, Mexico
Hospital Puerta de Hierro
🇲🇽Zapopan, Mexico
Academisch Medisch Centrum Universiteit van Amsterdam
🇳🇱Amsterdam, Netherlands
Medisch Spectrum Twente
🇳🇱Enschede, Netherlands
Universitair Medisch Centrum Groningen
🇳🇱Groningen, Netherlands
Elkerliek Ziekenhuis
🇳🇱Helmond, Netherlands
SBEU HPE Kemerovo State Medical Academy
🇷🇺Kemerovo, Russian Federation
Bakoulev Scientific Center For Cardiovascular Surgery Rams
🇷🇺Moscow, Russian Federation
FGBU Research Institute of Rheumatology named V.A.Nasonova
🇷🇺Moscow, Russian Federation
City Hospital #3
🇷🇺Tomsk, Russian Federation
Hosp Univ A Coruna
🇪🇸A Coruna, Spain
Hosp. Punta de Europa
🇪🇸Algeciras / Cadiz, Spain
Hosp Clinic de Barcelona
🇪🇸Barcelona, Spain
Hosp Univ Vall D Hebron
🇪🇸Barcelona, Spain
Hosp. Univ. de Basurto
🇪🇸Bilbao, Spain
Hosp Reina Sofia
🇪🇸Cordoba, Spain
Complejo hospitalario de Granada
🇪🇸Granada, Spain
Hosp. Univ. 12 de Octubre
🇪🇸Madrid, Spain
Hosp. Clinico Univ. de Santiago
🇪🇸Santiago de Compostela, Spain
Hosp. Virgen Del Rocio
🇪🇸Sevilla, Spain
Sahlgrenska Universitetssjukhuset
🇸🇪Göteborg, Sweden
Universitetssjukhuset i Lund
🇸🇪Lund, Sweden
Universitetssjukhuset Orebro
🇸🇪Orebro, Sweden
Akademiskt Specialistcentrum centrum för reumatologi
🇸🇪Stockholm, Sweden
Akademiska Sjukhuset
🇸🇪Uppsala, Sweden
HFR Fribourg - Hôpital Cantonal
🇨ðŸ‡Fribourg, Switzerland
Kaohsiung Veterans General Hospital
🇨🇳Kaohsiung, Taiwan
Chang Gung Medical Foundation
🇨🇳Kaohsiung, Taiwan
Taichung Veterans General Hospital
🇨🇳Taichung, Taiwan
NHS Grampian - Aberdeen Royal Infirmary (ARI)
🇬🇧Aberdeen, United Kingdom
Nevill Hall Hospital
🇬🇧Abergavenny, United Kingdom
University Hospital Monklands
🇬🇧Airdrie, United Kingdom
Royal Free London NHS Foundation Trust Barnet Hospital
🇬🇧Barnet, United Kingdom
Wolfson Centre Royal United Hospitals
🇬🇧Bath, United Kingdom
Glasgow Royal Infirmary
🇬🇧Glasgow, United Kingdom
Hull Royal Infirmary
🇬🇧Hull, United Kingdom
Leeds Teaching Hospitals NHS Trust Chapel Allerton Hospital
🇬🇧Leeds, United Kingdom
Central Manchester University Hospitals NHS Foundation Trust
🇬🇧Manchester, United Kingdom
The Newcastle upon Tyne Hospitals NHS Trust - Freeman Hospit
🇬🇧Newcastle Upon Tyne, United Kingdom
Queen Alexandra Hospital
🇬🇧Portsmouth, United Kingdom
Shirley Caldwell
🇬🇧Salford, United Kingdom
Southampton General Hospital
🇬🇧Southampton, United Kingdom
Haywood Hospital
🇬🇧Staffordshire, United Kingdom
Stamford and Rutland hospital
🇬🇧Stamford, United Kingdom
Wishaw General
🇬🇧Wishaw, United Kingdom