Alveolar-capillary Reserve After Exercise in Chronic Obstructive Pulmonary Disease (COPD) (COP-DTPA)
- Conditions
- Chronic Obstructive Pulmonary Disease
- Interventions
- Other: Acute exercise bout on visit 2 and 3
- Registration Number
- NCT06287476
- Lead Sponsor
- Rigshospitalet, Denmark
- Brief Summary
It is unknown whether individuals with COPD exhibit abnormal alveolar-capillary breaching during exercise, and whether this contributes to exertional dyspnoea. The aim of this study is to investigate whether individuals with COPD exhibit an abnormal increase in alveolar-capillary breaching during exertion, as indicated by an increase alveolar-capillary permeability with a concomitantly exacerbated increase in lung tissue mass.
- Detailed Description
It is unknown whether individuals with COPD exhibit abnormal alveolar-capillary breaching during exercise, and whether this contributes to exertional dyspnoea. The aim of this study is to investigate whether individuals with COPD exhibit an abnormal increase in alveolar-capillary breaching during exertion, as indicated by an increase alveolar-capillary permeability with a concomitantly exacerbated increase in lung tissue mass. The study participants include a control group and a group with COPD (GOLD I-III). Participants are undergoing three study days: (1) Measurement of maximal aerobic capacity and lung function test, (2) lung tissue mass and alveolar-capillary permeability is measured at rest and again 2 hours later, immediately after the participant has exercised on a bicycle ergometer and (3) supine cardiac output and pulmonary capillary blood volume will be measured at rest and immediately after exercise.
Recruitment & Eligibility
- Status
- NOT_YET_RECRUITING
- Sex
- All
- Target Recruitment
- 32
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Control Group Acute exercise bout on visit 2 and 3 This arm consist of only healthy participants (age (+/- 3 years) and sex matched to the COPD group), which will undergo three study visits COPD group Acute exercise bout on visit 2 and 3 This arm consist of only COPD patients, which will undergo three study visits
- Primary Outcome Measures
Name Time Method Rest-to-exercise pulmonary DTPA clearance change after exercise in COPD vs. controls Measured at study day 2 The physiological change from rest to exercise in DTPA clearance
- Secondary Outcome Measures
Name Time Method Pulmonary DTPA clearance at rest in COPD vs. controls Measured at study day 2 Pulmonary DTPA clearance measured by pulmonary DTPA clearance at rest
Rest-to-exercise change in lung tissue mass in COPD vs. controls Measured at study day 2 The physiological change from rest to exercise in lung tissue mass measured by low-dose CT-scan
Pulmonary DTPA clearance after exercise in COPD vs. controls Measured at study day 2 Pulmonary DTPA clearance measured by pulmonary DTPA clearance after exercise
Trial Locations
- Locations (1)
Center For Physical Activity Research, Rigshospitalet
🇩🇰Copenhagen, Denmark