Breath synchronized electrical stimulation of the abdominal wall muscles to prevent respiratory muscle atrophy during the acute stages of mechanical ventilation therapy

Completed

• Conditions: respiratory muscle weakness due to mechanical ventilation; weaning failure; 10028302; 10013369

• Registration Number: NL-OMON46155
• Lead Sponsor: Intensive care

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 20

Inclusion Criteria

- informed consent
- age > 18 year
- invasive mechanical ventilation less than 72 hours
- expected duration of MV after inclusion > 72 hours

Exclusion Criteria

- no visible abdominal wall muscles, assessed with ultrasound during routine care
- cardiac pacemaker
- congenital myopathies and/or existing central or peripheral neuropathies
- recent abdominal surgery within four weeks prior to study inclusion
- refractory / uncontrolled epilepsy
- BMI > 35
- pregnancy

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study endpoint is the thickness of the abdominal wall muscles during<br /><br>end-inspiration (ITabd) and end-expiration (ETabd), for both groups, as<br /><br>measured by ultrasound.</p><br>