Lipid, Glycemic, and Insulin Responses to Meals Rich in Different Fatty Acids

Not Applicable

Completed

• Conditions: Type 2 Diabetes Mellitus

• Registration Number: NCT00479791
• Lead Sponsor: University of Texas Southwestern Medical Center

Brief Summary

A meal rich in very-long chain omega-3 fatty acids or oleic acid may lower postprandial insulin levels in comparison to a meal rich in linoleic acid or palmitic acid. A meal rich in very long-chain omega-3 fatty acids may lower postprandial triglyceride levels compared to other fatty acids.

Detailed Description

Research Design and Methods: Test meals rich in palmitic acid, linoleic acid, oleic acid, and eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and containing 1,000 kcal each were administered in a randomized cross-over design every 3 to 4 days to 11 patients with T2DM. Serum insulin, glucose, and triglycerides concentrations were measured for 360 minutes. All subjects received an isoenergic diet of constant composition throughout the study.

Study Timeline

• Study Start: 1997-04
• Study Completion: 1999-06
• Status Verified: 2007-05
• Study First Submitted: 2007-05-24
• Study First Submitted QC: 2007-05-25
• Last Update Submitted: 2007-05-25
• Study First Posted: 2007-05-28
• Last Update Posted: 2007-05-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 11

Inclusion Criteria

• Type 2 diabetes mellitus not on insulin therapy

Exclusion Criteria

• Thyroid, renal, or hepatic disease, uncontrolled hypertension, anemia, history of ketosis

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
Insulin, and glucose	15 days

Secondary Outcome Measures

Name	Time	Method
Triglycerides	15 days

Trial Locations

Locations (1)

UT Southwestern Medical Center at Dallas; 🇺🇸 Dallas, Texas, United States