Functional Correlates of Bipolar Disorders and Effects of the Psychoeducation. Assessment by Functional and Anatomic Neuroimaging.
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Conditions Influencing Health Status
- Sponsor
- University Hospital, Grenoble
- Enrollment
- 45
- Locations
- 1
- Primary Endpoint
- fMRI measurement (neurophysiological [fMRI - activation and functional connectivity])
- Status
- Completed
- Last Updated
- 12 years ago
Overview
Brief Summary
This research project follows two main objectives: 1) Assess anatomical and functional cerebral abnormalities in bipolar disorder. 2) Evaluate anatomical and functional changes after the application of a psychoeducational program in these patients. Specifically, this project aims to assess neurophysiological (fMRI - activation and functional connectivity) and neuroanatomical (morphometry and diffusion tensor imaging) specificities related to bipolar disorders and the therapeutic response to the psychoeducation. The results of this thesis project would also contribute to the validation of a pathophysiological model of the bipolar disorder.
Investigators
AdministrateurDRC
Professor
University Hospital, Grenoble
Eligibility Criteria
Inclusion Criteria
- •clinical diagnosis of bipolar disorders
- •euthymic (Montgomery and Asberg depression rating scale \< 10, Young Mania rating scale \< 10)
Exclusion Criteria
- •other concomitant psychiatric disorders
Outcomes
Primary Outcomes
fMRI measurement (neurophysiological [fMRI - activation and functional connectivity])
Time Frame: measurements were performed at T1 and T2 (up to 3 months)
measurements were performed before (T1) and after (T2) educational program of 12 sessions .One session last one hour and half once a week (they come at the hospital for all sessions : i.e. during 12 weeks). Thus, T1 to T2 is 3 months (average).