Functional Correlates of Bipolar Disorders and Effects of the Psychoeducation. an fMRI Study

Not Applicable

Completed

• Conditions: Conditions Influencing Health Status; Bipolar Disorders

• Registration Number: NCT01821469
• Lead Sponsor: University Hospital, Grenoble

Brief Summary

This research project follows two main objectives: 1) Assess anatomical and functional cerebral abnormalities in bipolar disorder. 2) Evaluate anatomical and functional changes after the application of a psychoeducational program in these patients. Specifically, this project aims to assess neurophysiological (fMRI - activation and functional connectivity) and neuroanatomical (morphometry and diffusion tensor imaging) specificities related to bipolar disorders and the therapeutic response to the psychoeducation. The results of this thesis project would also contribute to the validation of a pathophysiological model of the bipolar disorder.

Detailed Description

Not available

Study Timeline

• Study Start: 2011-05
• Study First Submitted: 2012-11-06
• Study First Submitted QC: 2013-03-29
• Study First Posted: 2013-04-01
• Primary Completion: 2013-12
• Study Completion: 2013-12
• Status Verified: 2014-01
• Last Update Submitted: 2014-01-27
• Last Update Posted: 2014-01-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 45

Inclusion Criteria

• clinical diagnosis of bipolar disorders
• euthymic (Montgomery and Asberg depression rating scale < 10, Young Mania rating scale < 10)

Exclusion Criteria

• other concomitant psychiatric disorders

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
fMRI measurement (neurophysiological [fMRI - activation and functional connectivity])	measurements were performed at T1 and T2 (up to 3 months)	measurements were performed before (T1) and after (T2) educational program of 12 sessions .One session last one hour and half once a week (they come at the hospital for all sessions : i.e. during 12 weeks). Thus, T1 to T2 is 3 months (average).

Trial Locations

Locations (1)

Ums Irmage; 🇫🇷 Grenoble, France