Discovering the Dynamics of Endothelial Shear Stress
- Conditions
- arteriosclerosiscoronary heart disease10003216
- Registration Number
- NL-OMON35323
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 40
Group A:
1) Healthy individuals aged between 18 and 45 years old.
2) Not known with any clinical significant disease
3) Not using any prescription medication
4) Non-smoking
Group B:
1) Patients aged equal to or greater than (*) 45 years.
2) Known with an elevated LDL cholesterol (LDL > 90th percentile) with or without LDLc lowering therapy
Group A and B: ;1) Current active inflammatory diseases.
2) Any clinically significant medical condition that could interfere with the conduct of the study.
3) Known with hypertension (>15 years) , cardiac hypertrophy, cardiac failure (NYHA class I-IV) or any form of ischemic heart disease.
4) Standard contra-indications to MRI.
5) Inability or unwillingness to comply with the protocol requirements, or deemed by investigator to be unfit for the study.
6) Contra-indications to salbutamol and / or nitroglycrine;For group A only:
1) Previous clinical significant vaccination reactions
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p> The absolute difference between baseline endothelial shear stress before and<br /><br>after an endothelial dependent and independent vasodilator. </p><br>
- Secondary Outcome Measures
Name Time Method <p>The association between the absolute flow-mediated vasodilatation (mm) in the<br /><br>brachial artery and endothelial shear stress in N/m2.<br /><br>Tertiary outcome: The association between the absolute flow-mediated<br /><br>vasodilatation in the brachial artery and endothelial shear stress in N/m2<br /><br>during an inflammatory respons.<br /><br>. </p><br>