PRP Prevents Recurrence of Intrauterine Adhesions
- Conditions
- Intrauterine Adhesion
- Interventions
- Procedure: gelProcedure: Platelet-rich plasma
- Registration Number
- NCT03629132
- Lead Sponsor
- Yanhong Deng
- Brief Summary
Effect of platelet-rich plasma (PRP) on uterine scar fibrosis, endometrial receptivity and pregnancy outcome in patients with severe intrauterine adhesions
- Detailed Description
1. Inclusion criteria: patients with intrauterine adhesions (AFS score \>9 points); age 21 to 40 years old, with fertility requirements.
2. Study design:prospective, randomized controlled cohort study, patients with intrauterine adhesions were randomized into two groups, the control group and the intervention group (intraoperative and postoperative 1 week postoperative PRP). The surgical procedures and postoperative medication regimens were the same.
3. Compare the biochemical pregnancy rate, clinical pregnancy rate, abortion rate and live birth rate after hysteroscopic resection in PRP group and control group, and explore the effect of PRP on pregnancy outcome after intrauterine adhesion.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- Female
- Target Recruitment
- 60
Patients with intrauterine adhesions (AFS score >9 points); age 21 to 40 years old, with fertility requirements -
Endometrial tuberculosis, endometrial polyps, uterine submucosal fibroids, endometrial hyperplasia, endometrial malignant lesions, premature ovarian failure, chromosomal abnormalities
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Gel gel Self-crosslinking sodium hyaluronate gel PRP Platelet-rich plasma Platelet-rich plasma
- Primary Outcome Measures
Name Time Method AFS score 1 year AFS score
- Secondary Outcome Measures
Name Time Method