Comparing efficacy of two medicines in treating the increase in heart rate and blood pressure that occurs during laparoscopic surgery.
Not Applicable
- Conditions
- Health Condition 1: K87- Disorders of gallbladder, biliarytract and pancreas in diseases classified elsewhere
- Registration Number
- CTRI/2023/05/053098
- Lead Sponsor
- Dr.Darryl baby
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1.Age between 18-50 years.
2.American society of Anesthesiologists physical status [ASA] grade I and II.
3.Elective laparoscopic surgeries of less than 4 hours in duration.
Exclusion Criteria
1.Patients with a baseline Heart rate of less than 65 bpm and baseline blood pressure of < 90/50 mm of Hg.
2.Patients with cardiac comorbidities (IHD, VHD, CCF, Arrythmias, pacemaker dependent).
3.Patients on Beta blockers, Verapamil or Diltiazem.
4.Pregnant patients.
5.Patients with BMI > 30 KG/M2.
6.Anticipated difficult airway.
7.Patients with uncontrolled hypertension ( >140/90mm of Hg).
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The primary outcome we are expecting is reduction in blood pressure and heart rate after giving two premedications ivabradine and clonidine and to compare the efficacy by percentile measurement.Timepoint: <br/ ><br>.5 min before induction, 3 minutes after induction <br/ ><br>â?¢ 1 minute, 3 minutes, 5 minutes and after laryngoscopy and intubation. <br/ ><br>â?¢ At surgical incision: 1 minute, 3 minutes, 5 minutes after surgical incision. <br/ ><br>â?¢At insufflation of CO2, 1 minute and every 3 minutes till desufflation <br/ ><br>â?¢ At 1 minute interval from the time of reversal to 5 minutes after extubation.
- Secondary Outcome Measures
Name Time Method To compare the effect of ivabradine and clonidine administers as premedication on the recovery profile in these patients.Timepoint: Expecting similar reduction in blood pressure,heart rate post surgery in recovery room upto 1 hour post extubation and to also record any adverse effects of premedicaions given and to check whether it has improved recovery status by assessing pain score. <br/ ><br>