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临床试验/NCT07177261
NCT07177261招募中不适用

Inter-Brain Synchrony as a Neural Mechanism of Social Connection in Schizophrenia

University of California, Los Angeles1 个研究点 分布在 1 个国家目标入组 100 人开始时间: 2025年11月11日最近更新:
干预措施

试验速览

阶段
不适用
状态
招募中
入组人数
100
试验地点
1
主要终点
Interbrain synchrony

研究概览

简要总结

The goal of this clinical trial is to investigate for the first time in people with schizophrenia a neural mechanism that is thought to facilitate the formation of social connections - inter-brain synchrony - in order to improve scientific understanding of the neural mechanisms of social dysfunction in the disorder, and to provide a basis for the development of new and better treatments to improve social functioning and connectedness in the illness. The main questions it aims to answer are:

  1. Investigate inter-brain synchrony as a neural mechanism of social connection in schizophrenia
  2. Manipulate social closeness and test for effects on inter-brain synchrony across groups

The investigators will compare results from people with schizophrenia to a healthy comparison group (controls) who do not have psychotic disorders to see if inter-brain synchrony is greater in controls. Investigators will also compare measures of inter-brain synchrony before and after the social closeness manipulation to see if inter-brain synchrony changes with increasing closeness.

Participants will:

  • Have a clinicial diagnostic interview and be assessed for clinical symptoms
  • Have an EEG recorded while interacting with another person. Participants will first work with the other person to draw a figure, and then tap fingers together. Participants will then either undergo the experimental manipulation to increase social closeness (called, "fast friends") or undergo the control condition that does not increase social closeness (called "small talk"). Participants will then repeat the drawing and finger tapping assessment.
  • After completing the experimental or control condition, participants will then repeat the procedure with the other condition that was not yet done.
  • Be interviewed on the number and quality of social interactions.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Crossover
主要目的
Basic Science
盲法
None

入排标准

年龄范围
18 Years 至 65 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • sufficient English fluency to comprehend procedures
  • clinical group will include individuals with a DSM-5 diagnosis of schizophrenia who are clinically stable (outpatients, with no hospitalizations 3 months prior to enrollment and no medication changes 1 month prior to enrollment)
  • members of the community without a psychotic disorder, schizophrenia-spectrum disorder, or current major mood disorder, nor history of a first-degree relative with a psychotic disorder.

排除标准

  • evidence of IQ < 70 or developmental disability
  • history of significant neurological disease, serious head injury, or significant current substance use (moderate or severe substance use disorder in the last 3 months, positive urine toxicology screen on the day of assessment, or sedatives/anxiolytics taken within 12 hours of the assessment)

研究组 & 干预措施

Fast Friends

Experimental

Participants will interact with another person while both have their EEG recorded. Participants will ask and answer 12 questions with the other person that become increasingly personal in nature, e.g., "When did you last cry in front of another person? By yourself?"

干预措施: Fast Friends (Behavioral)

Small Talk

Active Comparator

Participants will interact with another person while both have their EEG recorded. Participants will ask and answer 12 impersonal questions with the other person , e.g., "Do you prefer digital watches and clocks or the kind with hands? Why?"

干预措施: Small Talk (Behavioral)

结局指标

主要结局

Interbrain synchrony

时间窗: Interbrain synchrony will be measured immediately before and immediately following the procedure.

Circular correlations for 8-10Hz activity across electrodes and dyads

次要结局

  • Social Network Analysis(Measured at the start of the study only)
  • Behavioral measures of synchrony(Investigators will measure these during each of the two maniuplations (small talk and fast friends).)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Jonathan Wynn, PhD

Researcher

University of California, Los Angeles

研究点 (1)

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