NCT07189624尚未招募不适用
Effect of Acute Endurance Exercise on the Production of FGF21 and Follistatin in Patients With Hepatocellular Carcinoma
University Hospital, Clermont-Ferrand3 个研究点 分布在 1 个国家目标入组 12 人开始时间: 2025年12月1日最近更新:
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 12
- 试验地点
- 3
- 主要终点
- Systemic hepatokines rates (FGF-21 and follistatin)
研究概览
简要总结
The main purpose of the study is to characterize the production of hepatokines (FGF21 and Follistatin) in response to a submaximal exercise on an ergocycle, in patients with hepatocellular carcinoma. The effect of exercise on hepatokines and metabolites production in liver cancer patients is not known. Studying this production could help to provide relevant recommendations for training programming in these patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Hepatocellular carcinoma developed on cirrhosis
- •Cirrhosis of any etiology, defined by a liver elasticity measurement >15kPa or a history of cirrhosis decompensation
- •Hepatocellular carcinoma with indication for treatment by immunotherapy or chemoembolization
- •Child-Pugh scores A and B7
- •WHO score ≤ 2
- •Affiliation to french national social security system
排除标准
- •Hepatic encephalopathy grade II or higher
- •Bone metastasis
- •Surgery performed within 30 days prior to inclusion visit
- •Liver transplant
- •Muscle injury within 3 months of inclusion
- •Pregnant or breast-feeding women
- •Patients under legal protection (guardianship, curatorship, safeguard of justice)
- •Participation in another clinical trial within 10 days of inclusion
结局指标
主要结局
Systemic hepatokines rates (FGF-21 and follistatin)
时间窗: Baseline (pre-exercise), immediately after exercise, 1 hour after the end of exercise
Blood samples
次要结局
- Muscle pain assessment(Baseline (pre-exercise), immediately after exercise, 1 hour after the end of exercise)
- Muscle pain assessment(Baseline (pre-exercise), immediately after exercise, 1 hour after the end of exercise)
研究者
研究点 (3)
Loading locations...
相似试验
Unknown
不适用
Biological Consequences of an Ultra Endurance RaceExcess ExertionNCT03194022Hôpital Necker-Enfants Malades25
已完成
不适用
The Effects of High-Intensity Exercise on Biological AgeExerciseNCT05156918Loma Linda University35
Unknown
不适用
The Effect of Acute and Chronic Exercise at the Metabolic Syndrome and Markers of Inflammation in Obese SubjectsHealthyObesityNCT00700245Aarhus University Hospital100
已完成
不适用
Exercise as an Modulator of Immunological Risk Factors for OsteoporosisOsteoporosisNCT02765945East Tennessee State University43
已完成
不适用
Effect of an Exercise Bout in Plasma and Fecal ProfileHealthyNCT04244149Universidad Europea de Madrid40