Orexin Gene in Anorexia Nervosa

Recruiting

• Conditions: Anorexia Nervosa

• Registration Number: NCT06800898
• Lead Sponsor: Istituto Auxologico Italiano

Brief Summary

The objectives of this study will be to determine the methylation of the promoter of the Orexin A (OX-A) and B (OX-B) genes in young women (\> 18 years) with Anorexia Nervosa (AN), compared with a control group; and to evaluate the relationship of promoter methylation of the genes for OX-A and OX-B with the severity of the eating disorder, psychiatric comorbidities (in particular, depression), and sleep quality.

Detailed Description

Not available

Study Timeline

• Study Start: 2024-06-19
• Status Verified: 2025-01
• Study First Submitted: 2025-01-24
• Study First Submitted QC: 2025-01-24
• Last Update Submitted: 2025-01-24
• Study First Posted: 2025-01-30
• Last Update Posted: 2025-01-30
• Primary Completion: 2026-06-30
• Study Completion: 2026-06-30

Recruitment & Eligibility

• Status: RECRUITING
• Sex: Female
• Target Recruitment: 60

Inclusion Criteria

• Female sex
• Age 18 years and older
• Anorexia Nervosa
• Hospitalized at the Division of Eating and Nutrition Disorders, Istituto Auxologico Italiano, IRCCS, Piancavallo, Italy

Exclusion Criteria

• Absence of signed informed consent

Control group:

Inclusion Criteria:

• Female sex
• Age 18 years and older
• Body Mass Index between 18.5 and 24.9 kg/m2

Exclusion Criteria:

• Absence of signed informed consent
• Presence of any physical and mental pathology

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Orexin A promoter methylation	Baseline	Percentage of Orexin A promoter methylation
Orexin B promoter methylation	Baseline	Percentage of Orexin B promoter methylation

Trial Locations

Locations (1)

Istituto Auxologico Italiano IRCCS, Site Piancavallo; 🇮🇹 Oggebbio, Verbania, Italy