Effect of Amino Acids and Sugar Alcohols on Gastric Emptying and Release of Satiation Peptides in Humans
Not Applicable
Completed
- Conditions
- Endocrine System Diseases
- Interventions
- Dietary Supplement: 1.56 g L-LeucineDietary Supplement: 1.56 g L-TryptophanDietary Supplement: 0.52 g L-TryptophanDietary Supplement: 300 mL tap waterDietary Supplement: 50 g XylitolDietary Supplement: 75 g ErythritolDietary Supplement: 75 g GlucoseOther: 50 mg 13C-sodium acetate
- Registration Number
- NCT02563847
- Lead Sponsor
- University Hospital, Basel, Switzerland
- Brief Summary
With this study the investigators investigate the effects of amino acids (tryptophan in two different concentrations, leucin) and sugar alcohols (xylitol, erythritol) on satiety mechanisms.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 20
Inclusion Criteria
- Healthy normal weight subjects with a body-mass index of 19.0-24.9
- Healthy obese subjects with a body-mass index of > 30
- Normal eating habits (no diets; no dietary changes; no special dietary habits, such as vegetarian/vegan)
- Age 18-40 years
- Stable body weight for at least three months
Exclusion Criteria
- Smoking
- Substance abuse
- Regular intake of medications (except for oral contraceptives)
- Medical or psychiatric illness
- History of gastrointestinal disorders
- Food allergies
- Pregnancy, breast feeding
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description 1.56 g L-Leucine 1.56 g L-Leucine 1.56 g L-Leucine in 300 mL tap water (plus 50 mg 13C-sodium acetate) given via nasogastric tube 1.56 g L-Tryptophan 1.56 g L-Tryptophan 1.56 g L-Tryptophan in 300 mL tap water (plus 50 mg 13C-sodium acetate) given via nasogastric tube 75 g Glucose 50 mg 13C-sodium acetate 75 g Glucose in 300 mL tap water (plus 50 mg 13C-sodium acetate) given via nasogastric tube 1.56 g L-Leucine 50 mg 13C-sodium acetate 1.56 g L-Leucine in 300 mL tap water (plus 50 mg 13C-sodium acetate) given via nasogastric tube 0.52 g L-Tryptophan 0.52 g L-Tryptophan 0.52 g L-Tryptophan in 300 mL tap water (plus 50 mg 13C-sodium acetate) given via nasogastric tube Tap water 300 mL tap water 300 mL tap water (plus 50 mg 13C-sodium acetate) given via nasogastric tube 1.56 g L-Tryptophan 50 mg 13C-sodium acetate 1.56 g L-Tryptophan in 300 mL tap water (plus 50 mg 13C-sodium acetate) given via nasogastric tube 50 g Xylitol 50 g Xylitol 50 g Xylitol in 300 mL tap water (plus 50 mg 13C-sodium acetate) given via nasogastric tube 50 g Xylitol 50 mg 13C-sodium acetate 50 g Xylitol in 300 mL tap water (plus 50 mg 13C-sodium acetate) given via nasogastric tube 0.52 g L-Tryptophan 50 mg 13C-sodium acetate 0.52 g L-Tryptophan in 300 mL tap water (plus 50 mg 13C-sodium acetate) given via nasogastric tube 75 g Erythritol 75 g Erythritol 75 g Erythritol in 300 mL tap water (plus 50 mg 13C-sodium acetate) given via nasogastric tube 75 g Erythritol 50 mg 13C-sodium acetate 75 g Erythritol in 300 mL tap water (plus 50 mg 13C-sodium acetate) given via nasogastric tube 75 g Glucose 75 g Glucose 75 g Glucose in 300 mL tap water (plus 50 mg 13C-sodium acetate) given via nasogastric tube Tap water 50 mg 13C-sodium acetate 300 mL tap water (plus 50 mg 13C-sodium acetate) given via nasogastric tube
- Primary Outcome Measures
Name Time Method Effect of different aminoacids and sugar alcohols on secretion of satiation hormones changes from baseline to three hours after treatment Plasma concentrations of cholecystokinin are measured
- Secondary Outcome Measures
Name Time Method Effect of different aminoacids and sugar alcohols on gastric emptying changes from baseline to four hours after treatment measured by C13 breath test
Trial Locations
- Locations (1)
University Hospital Basel, Phase 1 Research Unit
🇨ðŸ‡Basel, Switzerland