Efficacy of a moxidectin versus ivermectin in subjects infected by Strongyloides stercoralis
Not Applicable
Completed
- Conditions
- Strongyloides stercoralis infectionInfections and Infestations
- Registration Number
- ISRCTN11983645
- Lead Sponsor
- Swiss Tropical and Public Health Institute (Swiss TPH)
- Brief Summary
2017 results in: https://www.ncbi.nlm.nih.gov/pubmed/28369530 2018 results from embedded study in: https://www.ncbi.nlm.nih.gov/pubmed/29367294
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 120
Inclusion Criteria
1. Aged 18 years or over
2. Infected with S. stercoralis infection
3. Absence of major systemic illnesses
4. Written informed consent signed
Exclusion Criteria
1. Abnormal medical conditions or chronic disease
2. Negative diagnostic result for soil-transmitted helminthes infection
3. No written informed consent
4. Recent anthelminthic treatment (past 2 months)
5. Pregnancy
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Strongyloides stercoralis infection status is determined 21 days after treatment using the Baermann method in 2 stool samples.
- Secondary Outcome Measures
Name Time Method <br> 1. Adverse events are measured through self-reporting 3, 24, 48 and 72 hours after treatment<br> 2. S. stercoralis infection intensity is measured using a larval count in stool samples 21 days after treatment in relation to baseline infection intensity (LRR)<br> 3. O. viverrini and other helminth infection status and intensity is measured using stool samples (Kato Katz method) 21 days after treatment<br>