Caloric Restriction With Optimal Nutrition and Aging Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 71
- 试验地点
- 1
- 主要终点
- Telomere Length
研究概览
简要总结
The purpose of this study is to see whether people who have restricted the number of calories they eat for a long period of time, compared to normal-eating and obese people, have markers of cellular aging that look younger.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Calorie restricting group: Self-reported caloric restriction for at least two years
- •Calorie restriction group: BMI below 23
- •Normal eating control: Normal eating (no history of caloric restriction) for two years
- •Normal eating control: BMI below 30
- •Obese comparison group: BMI above 30
- •Obese comparison group: Normal eating (no history of caloric restriction) for two years
排除标准
- •Regular smoker for the past six months
结局指标
主要结局
Telomere Length
时间窗: One day
This study is not a clinical trial, but the UCSF Committee on Human Research requires registration with clinicaltrials.gov. It is a ONE TIME POINT study, where we get a simple blood draw from people from three groups - calorie restricting, normal eating, and obese. Therefore, there IS NO FOLLOW UP/time frame. The outcome measure is assessed on the day of the study. Telomere length is a marker of cellular aging and is used to understand how the cells are aging. We will investigate whether long-term caloric restriction is associated cross-sectionally with longer telomere length (less aging).
次要结局
未报告次要终点