Long-term Caloric Restriction and Cellular Aging Markers
- Conditions
- Aging
- Registration Number
- NCT01256840
- Lead Sponsor
- University of California, San Francisco
- Brief Summary
The purpose of this study is to see whether people who have restricted the number of calories they eat for a long period of time, compared to normal-eating and obese people, have markers of cellular aging that look younger.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 71
- Calorie restricting group: Self-reported caloric restriction for at least two years
- Calorie restriction group: BMI below 23
- Normal eating control: Normal eating (no history of caloric restriction) for two years
- Normal eating control: BMI below 30
- Obese comparison group: BMI above 30
- Obese comparison group: Normal eating (no history of caloric restriction) for two years
- Regular smoker for the past six months
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Telomere Length One day This study is not a clinical trial, but the UCSF Committee on Human Research requires registration with clinicaltrials.gov. It is a ONE TIME POINT study, where we get a simple blood draw from people from three groups - calorie restricting, normal eating, and obese. Therefore, there IS NO FOLLOW UP/time frame. The outcome measure is assessed on the day of the study. Telomere length is a marker of cellular aging and is used to understand how the cells are aging. We will investigate whether long-term caloric restriction is associated cross-sectionally with longer telomere length (less aging).
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
University of California
🇺🇸San Francisco, California, United States