Positive End-expiratory Pressure and Esophageal Catheter Optimal Calibration Volume in ARDS Patients
- Conditions
- ARDS
- Registration Number
- NCT02945917
- Lead Sponsor
- Magni Federico
- Brief Summary
The use of esophageal balloon catheter to estimate pleural pressure has gained renewed popularity in recent years. Indeed, measurement of transpulmonary pressure may allow a more pathophysiological-based approach to ventilator strategy in acute respiratory distress syndrome (ARDS) patients. Nevertheless, it is well known that esophageal balloon catheter derived parameters can be influenced by several patient-related or technical-related factors.
During a PEEP trial, the investigators will observe in-vivo the esophageal pressure and derived measurements obtained using different esophageal balloon calibration volumes.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 16
Inclusion Criteria
- Diagnosis of ARDS with a PEEP of at least 8 cmH2O
- Fraction of inspired oxygen not higher than 80%
- Intubated and ventilated in Volume Control Ventilation mode set by the attending physician according to clinical criteria
- Need of continuous sedation through intravenous anesthetics and full neuromuscular blockade
Exclusion Criteria
- Been pregnant or breastfeeding
- Hemodynamic instability
- Presence of tracheobronchial fistula
- Known pneumothorax
- Leak in airway circuitry
- Presence of any kind of inhalator therapy (e.g. Heliox, nitric oxide, anesthetic conserving device)
- Recent history of nasal trauma or lesion of nasal cavity
- Recent history of esophageal, gastrointestinal, ENT, thoracic or cardiac surgery (less than 2 months)
- Known or suspected esophageal varices
- Congenital, acquired or drug-induced hemostatic disorder
- Thrombocytopenia (less than 50000/mm3)
- Recent history of Traumatic Brain Injury or thoraco-abdominal trauma (less than 1 months)
- Rib or sternal fractures
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method transpulmonary pressure measured estimating pleural pressure through the esophageal balloon within 10 minutes after esophageal balloon volume changing
- Secondary Outcome Measures
Name Time Method End-expiratory lung volume within 60 minutes after PEEP changing
Trial Locations
- Locations (1)
UOC Anestesia e Rianimazione
🇮🇹Monza, Monza e Brianza, Italy