The Study of Using Esophageal Pressure to Guide the PEEP Setting in Abdominal Hypertension Patients Who Undergoing Mechanical Ventilation
- Conditions
- ARDSIntra-abdominal Hypertension
- Interventions
- Device: titrated setting peep
- Registration Number
- NCT01825304
- Lead Sponsor
- Nanjing Medical University
- Brief Summary
Intra-abdominal hypertension can increase the pleural pressure, and then end-expiratory transpulmonary pressures will be turn to negative, Pulmonary atelectasis/acute lung injury/acute respiratory distress syndrome will appear. In the group of people who suffering intra-abdominal hypertension, the investigators use the pressure of esophagus to speculate the Intrathoracic pressure, and to setting PEEP in order to decrease the happening of ALI/ARDS, which may decrease morbidity in this population.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 60
- intra-abdominal hypertension
- mechanical ventilation
- sedation
- underlying pulmonary disease
- age older than 60 years and younger than 18 years
- vital signs were not stable
- non voluntary
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description esophageal pressure ,titrated setting titrated setting peep - ARDSNet recommendations,peep titrated setting peep -
- Primary Outcome Measures
Name Time Method ventilator-free days 28d Comparison of two groups the duration of ventilation-free in 28d,ventilator-free day include weaning from mechanical ventilation more than 24h.
- Secondary Outcome Measures
Name Time Method mortality 28d 28-Day mortality include patients who giving up treatment due to critical condition
Trial Locations
- Locations (1)
Ventilator
🇨🇭Bern, Switzerland