Effect of Initial Empirical PEEP Setting on the Esophageal Pressure-guided PEEP Titration in ARDS

Completed

• Conditions: PEEP, Occult; ARDS, Human; Esophageal and Pleural Pressure
• Interventions: Other: PEEP adjustment

• Registration Number: NCT05442073
• Lead Sponsor: Peking Union Medical College Hospital

Brief Summary

Esophageal manometry was used as surrogate of pleural pressure to titrate positive end-expiratory pressure (PEEP) in ARDS patients. However, Absolute values of esophageal pressure (Pes) could be affected by the PEEP setting. In moderate to severe ARDS patients, the end-expiratory Pes changed differently with PEEP adjustment. and the esophageal phenotypes could be divided into type I and type II. with Type I （ΔPes≥30%ΔPEEP）and Type II（ΔPes\<30%ΔPEEP）.

Detailed Description

Not available

Study Timeline

• Study Start: 2022-03-01
• Primary Completion: 2022-05-31
• Status Verified: 2022-06
• Study First Submitted: 2022-06-28
• Study First Submitted QC: 2022-06-28
• Last Update Submitted: 2022-06-28
• Study Completion: 2022-06-29
• Study First Posted: 2022-07-01
• Last Update Posted: 2022-07-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 18

Inclusion Criteria

• aged over 18 all the moderate to severe ARDS patients invasive mechanical ventilation

Exclusion Criteria

• aged<18 contraindication to esophageal catheter

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Type I: ΔPes≥30%ΔPEEP	PEEP adjustment	-
Type II: ΔPes<30%ΔPEEP	PEEP adjustment	-

Primary Outcome Measures

Name	Time	Method
the changes of esophageal pressure during the PEEP titration	March 1st to May 31st, 2022

Trial Locations

Locations (1)

Peking Union Medical College Hospital; 🇨🇳 Beijing, Beijing, China