Comparison of ultrasound assessment for diaphragmatic workload during spontaneous breathing trial between Automatic tube compensation and pressure support ventilatio

Phase 4

• Conditions: intubatedmechanical ventilatedweaningdiaphragm workloadsuccessful extubation predictiondiaphragm thickness fractiondiaphragm excursionpeak contraction velocitypeak relaxation velocityvelocity-time integralTDI-derived maximal relaxation rate; intubated; mechanical ventilated; weaning; diaphragm workload; successful extubation prediction; diaphragm thickness fraction; diaphragm excursion; peak contraction velocity; peak relaxation velocity

• Registration Number: TCTR20210317004
• Lead Sponsor: Self-funded

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2021-03-17
• Study Completion: 2022-02-28
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Pending (Not yet recruiting)
• Sex: All
• Target Recruitment: 48

Inclusion Criteria

admitted to ICU in Ramathibodi hospital
intubated and mechanically ventilated more than 48 hours
passed to spontaneous breathing trial

Exclusion Criteria

Contra-indicated for diaphragm ultrasound
Diaphragm pathology
Diagnosed neuromuscular pathology e.g. MG, ALS
Pregnancy
Inability to participate until the end of the trial
Withdrawal of informed consent
The incomplete data collection form

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
difference of diaphragm workload between ATC and PSV 30 minutes diaphragm thickness fraction

Secondary Outcome Measures

Name	Time	Method
successful extubation prediction 2 hours diaphragm thickness fraction, diaphragm excursion, peak contraction velocity, peak relaxation velocity, velocity-time integral, TDI-derived maximal relaxation rate