Comparison of respiratory muscle diaphragm by ultrasound with abnormal breathing to predict discharge from ventilator

Not Applicable

• Conditions: Health Condition 1: - Health Condition 2: M049- Autoinflammatory syndrome, unspecifiedHealth Condition 3: J22- Unspecified acute lower respiratory infection

• Registration Number: CTRI/2022/03/041551
• Lead Sponsor: Raju shakya

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 4 April 2022

Recruitment & Eligibility

• Status: ot Yet Recruiting
• Sex: Not specified
• Target Recruitment: 0

Inclusion Criteria

(a) age > 18 years;

(b) mechanically ventilated for more than 48 hrs;

(c) clinical improvement of the underlying acute cause of respiratory failure;

(d) adequate cough reflex;

(e) absence of excessive and/or purulent tracheobronchial secretion;

(f) stable cardiovascular status

(i.e. heart rate <120 beats/min; systolic blood pressure : 90â??160 mmHg; &

no/minimal vasopressor use, i.e., dopamine or dobutamine <5 μg/kg/min or

noradrenaline <0.05 μg/kg/min);

(g) stable metabolic status (i.e. electrolytes and glucose within normal range,

body temperature <38 °C, hemoglobin >=8â??10 g/dL;

(h) adequate oxygenation (SaO2) >92 % with FiO2 <=0.5 or

PaO2/FiO2 >=150 mmHg, both with PEEP <=8 cmH2O;

(i) adequate pulmonary function (i.e., RR <=30 breaths/min with VT >=5 mL/kg ideal body

weight (IBW) and no significant respiratory acidosis; and

(j) Richmond Agitation and Sedation Scale score ranging between â??1 and +1

Exclusion Criteria

(a) age <18 years;

(b) pregnancy;

(c) presence of thoracostomy, pneumothorax, or pneumomediastinum;

(d) presence of flail chest or rib fractures;

(e) neuromuscular disease;

(f) use of neuromuscular blockers in the previous 48 h of study; and

(g) history or new detection of paralysis or paradoxical movement of a single hemidiaphragm

on diaphragmatic ultrasonography.

Study & Design

• Study Type: Observational
• Study Design: Not specified