Effect of Nd-YAG Laser on Hypertrophic Scar

Not Applicable

Completed

• Conditions: Hypertrophic Scar
• Interventions: Procedure: Nd- YAG laser at 532nm wavelength

• Registration Number: NCT06347081
• Lead Sponsor: Cairo University

Brief Summary

A hypertrophic scar is a serious health concern in the industrialized world. Two groups of patients were treated with standard medical care. The experimental group received additional laser therapy. scar assessment was measured immediately before treatment, after 3, and 7 months.

T test for comparison before-treatment between the control and study groups. ANOVA with repeated measures test for comparison among other measures.

Detailed Description

Background: A hypertrophic scar is a serious health concern in the industrialized world. Objective: The impact of this study was to investigate the effect of the Nd-YAG laser at 532nm wavelength on hypertrophic scars. Patients and methods: Forty male and female patients with hypertrophic scars, ranging in age from fifteen to forty-five, were recruited from the burn patients' clinic within the Faculty of Physical Therapy, Cairo University, for this study. They were randomized into two equivalent groups. Group A (the control group) consisted of 20 patients who were given standard medical care, nursing, physiotherapy, and a sham laser during the course of treatment. In contrast, Group B (the study group) consisted of 20 patients who were given 532 nm laser radiation in addition to standard medical care, nursing, and physiotherapy. Treatment was conducted every 2 weeks for 14 sessions. Outcome measures included Vancouver Scar Scale score and scar volume. The assessment procedures were applied before the initiation of treatment (Pre), after 3 months (Post1) and after 7 months (Post 2) from the beginning of the treatment.

Study Timeline

• Study Start: 2022-05-01
• Primary Completion: 2024-02-28
• Study Completion: 2024-02-28
• Study First Submitted: 2024-03-27
• Status Verified: 2024-04
• Study First Submitted QC: 2024-04-02
• Last Update Submitted: 2024-04-02
• Study First Posted: 2024-04-04
• Last Update Posted: 2024-04-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• Adult patients with hypertrophic scars.

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Exclusion Criteria

• Patients were excluded if they had taken oral retinoids in the last year.
• Patients had any skin defects.
• Patients had any history of photosensitivity.
• Patients experienced active skin diseases in the treatment regions (such as psoriasis, cancer, or autoimmune disease).

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Laser group	Nd- YAG laser at 532nm wavelength	Patients received 532 nm laser radiation in addition to standard medical care, nursing, and physiotherapy.
Placebo	Nd- YAG laser at 532nm wavelength	Patients received standard medical care, nursing, physiotherapy, and a sham laser during the course of treatment

Primary Outcome Measures

Name	Time	Method
hypertrophic scar maturation	before treatment,12 weeks, and then 28 weeks of the treatment.	Changes in the scars' color, vascularity, elevation, and pliability were evaluated and scored using the Vancouver scale (VSS). VSS is from 0 to 14. A lower value indicates a better scar.
hypertrophic scar volume	before treatment,12 weeks, and then 28 weeks of the treatment.	Scar volume was determined using the negative-positive moulage method.

Trial Locations

Locations (1)

Faculty of Physical Therapy; 🇪🇬 Cairo, Egypt