To compare between intravenous Levetiracetam and Intravenous Phenytoin which is better as second Line anticonvulsant in paediatric status Epilepticus
- Conditions
- Health Condition 1: G968- Other specified disorders of central nervous system
- Registration Number
- CTRI/2020/12/029566
- Lead Sponsor
- Mamum Kartek
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 0
1. Presenting with generalized tonic clinic ,generalized clonic,generalized tonic,generalised myoclonic ,focal tonic or focal clonic seizures
2. Children who had received 2 doses of midazolam
3. Children who had received 2 doses of midazolam for generalized convulsive seizures lasting more than 5 minutes and continued to have persistent or recurrent convulsions in the emergency department at least 5 minutes after the last dose of benzodiazepines
4. Patient on maintenance dose of phenytoin and Levetiracetam with bad compliance
1.Age <3 months and >15 years of age .
2. Children presenting with absence seizures or infantile spasms .
3. Convulsive status Epilepticus due to hypocalcemia,hypoglycaemia,hypercalcemia .
4. Patient had received second line Anticonvulsant during the episode of convulsive status epilepticus .
5. Patients with arrhythmia .
6. Patients allergic to Levetiracetam and phenytoin .
7. Patients already on maintenance dose of phenytoin and Levetiracetam with good compliance .
8. Seizure controlled with 2 doses of midazolam .
9. Parents / care providers not giving consent .
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Absence of clinically apparent seizures after 5 minutes of completion of trial drug infusion without additional anticonvulsants medication.Timepoint: 2 years
- Secondary Outcome Measures
Name Time Method Patients requiring further anticonvulsants to manage convulsive status epilepticus,recurrence of seizures, change in cardio respiratory parameter ,need for admission to PICU and any drug related serious adverse reactions .Timepoint: 2 years