Development and neurobiological investigation of a social-cognitive intervention for patients with schizophrenia
Phase 1
- Conditions
- F20-F29Schizophrenia, schizotypal and delusional disorders
- Registration Number
- DRKS00025907
- Lead Sponsor
- niversitätsklinikum Gießen und Marburg, Standort Marburg
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- 50
Inclusion Criteria
1) Signed informed consent
2) For all patients, a diagnosis in the schizophrenia spectrum according to ICD-10 criteria (F20.-29.)
Exclusion Criteria
1) Neurological pre-existing conditions
2) MRI incompatibility (detected by MRI screening)
3) Lack of ability to consent to study participation
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Reduction of negative symptoms in patients with schizophrenia as measured by the Scale for the Assessment of Negative Symptoms (SANS, post vs. pre intervention).
- Secondary Outcome Measures
Name Time Method 1) It is expected that during the intervention, the patient group will approach the control group in the pre-post comparison in the following endpoints:<br><br>i) Behavioral change in social-cognitive paradigms: <br>a) Prisoner's Dilemma Game<br>b) Probabilistic Decision Task<br>c) Social Memory Task<br><br>ii) fMRI - iomarkers identified from the above mentioned experimental paradigms<br><br>iii) Clinical and cognitive scales<br><br>2) Both groups (patients and controls) are expected to benefit from the intervention in the above mentioned endpoints<br>