Effectiveness of using herbs in treatment of non-infectious diarrhea in primary care unit network, Sirindhon hospital, Khonkae

Phase 2

Completed

• Conditions: on-infected acute diarrhea.; Ya-dhat-ban-job, Ya-leung-pid-sa-mut, Andrographis paniculata, non-infected randomised-controlled trial, primary care

• Registration Number: TCTR20230123007
• Lead Sponsor: Faculty of Pharmacy, Mahasarakham University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2022-09-20
• Study Start: 2023-01-23
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 83

Inclusion Criteria

1. Patients with acute diarrhea who have a loose stool at least three times per day or a mucus stool at least one time per day or a watery stool at least one time per day. Patients may also have nausea or vomit predominantly.
2. Present with the following symptoms: slightly fatigued, regular pulse, normal blood pressure, no sunken eyes, and capillary refill time less than 2 seconds.
3. Age between 20-60 years old
4. No fever
5. No blood in stool
6. Consent to take part in the study

Exclusion Criteria

1. Allergic to one of the three herbal formulas or the ingredients used in these formulas.
2. Previously received antibiotics or other medications for diarrhea.
3. Regularly taking anticoagulants or antiplatelets.
4. Being pregnant or planning to get pregnant at the time of the study.
5. Having one of these health conditions related to liver, renal, heart, diabetes, hypertension, and HIV.
6. Taking immunosuppressant.
7. Taking any medications which induce diarrhea, such as laxatives.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
umber of bowel movement Before intervention and three days after the intervention (Day 0, 1, 2, 3) Frequency

Secondary Outcome Measures

Name	Time	Method
umber of vomit Before intervention and three days after the intervention (Day 0, 1, 2, 3) Frequency,Abdominal camps Before intervention and three days after the intervention (Day 0, 1, 2, 3) Pain visual analog scales,Fatigue Three days after the intervention (Day 1, 2, 3) Patient were interviewed if the fatigue is recovered compare to yesterday.,Bowel movement Three days after the intervention (Day 1, 2, 3) Patient were interviewed if the bowel movement is recovered compare to yesterday.,Abdominal cramps Three days after the intervention (Day 1, 2, 3) Patient were interviewed if the abdominal is recovered compare to yesterday.,Nausea/Vomit Three days after the intervention (Day 1, 2, 3) Patient were interviewed if the nausea/vomit is recovered compare to yesterday.,Dehydration Three days after the intervention (Day 1, 2, 3) Patient were interviewed to assess dehydration whether it is recovered compare to yesterday.