Multimodal analgesia study of nefopam combined with ketorolac, paracetamol and gabapentin compare to morphine in postoperative unilateral total knee arthroplasty ; a double blind, randomized clinical trial

Not Applicable

• Conditions: pain in postoperative unilateral total knee arthroplasty patients; Pain; Total knee arthroplasty; multimodal analgesia; morphine

• Registration Number: TCTR20201228004
• Lead Sponsor: erdsin hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2020-12-28
• Study Completion: 2023-12-31
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Pending (Not yet recruiting)
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

1.Postoperative unilateral total knee arthroplasty patients.
2.Patients whose medial collateral ligament were not released
3.Underwent spinal block without morphine injection to subarachnoid space

Exclusion Criteria

1.Cannot give information about VAS
2.History of knee surgery same side of total knee arthroplasty
3.BMI equal or more than 40 kg/square meters
4.Underlying disease that are contraindicated to nefopam, ketorolac, paracetamol, gabapentin, morphine : chronic liver disease, cardiac or chronic renal failure(GFR < 90 ml/min/1.73m2), psychiatric disorder, alcohol abuse, glaucoma, peptic ulcer, inflammatory bowel disease, established, ischemic heart disease, suicidal idea
5.History of drug allergy to sulfonamides group
6.Allergy to aspirin, NSAIDs, selective COX-2 inhibitors

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Pain score 2,6,12,24 hours postoperative Visual analog scale

Secondary Outcome Measures

Name	Time	Method
Side effects and complications from multimodal analgesia and morphine 2,6,12,24 hours postoperative ask for symptoms