Genomic BRCA and Extensive ovArian Cancer Testing
- Conditions
- Fallopian Tube CancerEpithelial Ovarian CancerPeritoneal Cancer
- Registration Number
- NCT04027868
- Lead Sponsor
- ARCAGY/ GINECO GROUP
- Brief Summary
This is a prospective observational French multicenter cohort in patients with ovarian and/or primitive peritoneal and/or fallopian tubes carcinoma, histologically confirmed, with an advanced stage at diagnosis (stage III to IV FIGO 2014). The objective is to constitute a clinico-biological database that allows to correlate clinical and progressive features of ovarian cancer patients based on tumor genomics and molecular detected abnormalities.
- Detailed Description
This is a prospective observational French multicenter cohort in patients with ovarian and/or primitive peritoneal and/or fallopian tubes carcinoma, histologically confirmed, with an advanced stage at diagnosis (stage III to IV FIGO 2014). The objective is to constitute a clinico-biological database that allows to correlate clinical and progressive features of ovarian cancer patients based on tumor genomics and molecular detected abnormalities.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 1500
-
Patient older than 18 years.
-
Patient with ovarian and/or primitive peritoneal and/or fallopian tubes carcinoma, histologically confirmed, with an advanced stage at diagnosis (stage III to IV FIGO 2014)
-
Patient in first line therapy
-
Available tumor sample fixed in formalin and included in paraffin (FFPE):
- in pre-chemotherapy, insofar as possible
- having a sufficient tumor surface, with a final cellularity of at least 20%
-
Identification of a molecular genetics' cancer platform participant in GREAT and an onco-geneticists team working with the investigator team
-
Patient consenting her data to be collected and submitted through an automated processing
-
Patient beneficiary from the French social security
- Patient with a mucinous ovarian carcinoma
- Patient pregnant or breastfeeding
- Patient under legal protection (guardianship or court order) or unable to consent
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Correlation between Progression Free Survival (PFS) and the detected tumor genetic abnormalities From baseline until the date of progression or death, which ever occurs earlier, assessed up to 10 years
- Secondary Outcome Measures
Name Time Method Correlation between treatment response and the detected tumor genetic abnormalities Up to 10 years Correlation between age and the detected tumor genetic abnormalities Baseline Correlation between surgery resection status and the detected tumor genetic abnormalities Up to 10 years Correlation between histology status and the detected tumor genetic abnormalities Baseline Correlation between FIGO stage and the detected tumor genetic abnormalities Baseline Correlation between Overall survival (OS) and the detected tumor genetic abnormalities From baseline to death, assessed up to 10 years
Trial Locations
- Locations (136)
Clinique Tivoli
🇫🇷Bordeaux, France
Hôpital Privé d'Antony - Ramsay Santé
🇫🇷Antony, France
CH Arras
🇫🇷Arras, France
CH Auxerre
🇫🇷Auxerre, France
Institut Sainte Catherine
🇫🇷Avignon, France
Hôpital Général de Castres
🇫🇷Castres, France
Clinique Belharra
🇫🇷Bayonne, France
CH Côte Basque
🇫🇷Bayonne, France
Centre Hospitalier de Beauvais
🇫🇷Beauvais, France
CHRU Jean Minjoz
🇫🇷Besançon, France
Reims Icone
🇫🇷Bezannes, France
CH de Blois
🇫🇷Blois, France
Hôpital Avicenne
🇫🇷Bobigny, France
CHU de Bordeaux - Hôpital Pellegrin
🇫🇷Bordeaux, France
Institut Bergonié
🇫🇷Bordeaux, France
Polyclinique Bordeaux Nord
🇫🇷Bordeaux, France
Centre Hospitalier Fleyriat - BOURG-EN-BRESSE
🇫🇷Bourg-en-Bresse, France
CHU Brest
🇫🇷Brest, France
Hôpital Femme Mère Enfant
🇫🇷Bron, France
Centre François Baclesse
🇫🇷Caen, France
Centre Maurice Tubiana
🇫🇷Caen, France
CH de Cahors
🇫🇷Cahors, France
CH Carcassonne
🇫🇷Carcassonne, France
Medipole de Savoie
🇫🇷Challes-les-Eaux, France
CH Chalon sur Saone
🇫🇷Chalon-sur-Saône, France
Centre d'Oncologie et de Radiothérapie 37
🇫🇷Chambray-lès-Tours, France
CH Metropole Savoie
🇫🇷Chambéry, France
CHPC - Hôpital Louis Pasteur
🇫🇷Cherbourg, France
CH Cholet
🇫🇷Cholet, France
Centre Hospitalier de Chateauroux
🇫🇷Châteauroux, France
Hôpital Antoine Béclère
🇫🇷Clamart, France
Centre Jean Perrin
🇫🇷Clermont-Ferrand, France
CH Alpes Léman
🇫🇷Contamine-sur-Arve, France
Centre Hospitalier Sud Francilien (Site Gilles de Corbeil)
🇫🇷Corbeil-Essonnes, France
Clinique des Cèdres
🇫🇷Cornebarrieu, France
Clinique de Flandre
🇫🇷Coudekerque-Branche, France
Groupe Hospitalier public du Sud de l'Oise (GHPSO)
🇫🇷Creil, France
CHI Creteil
🇫🇷Créteil, France
Centre Georges François Leclerc
🇫🇷Dijon, France
CHU Dijon
🇫🇷Dijon, France
Institut de Cancérologie de Bourgogne - GRReCC
🇫🇷Dijon, France
Centre Hospitalier Intercommunal de Fréjus Saint Raphael
🇫🇷Fréjus, France
GH Mutualiste de Grenoble
🇫🇷Grenoble, France
Hôpital Privé Drôme Ardèche - Clinique Pasteur
🇫🇷Guilherand-Granges, France
Centre Hospitalier Marne-la-Vallée
🇫🇷Jossigny, France
Centre Hospitalier Départemental de Vendée
🇫🇷La Roche-sur-Yon, France
CHU Grenoble Alpes - Site Nord (La Tronche)
🇫🇷La Tronche, France
Hôpital André Mignot
🇫🇷Le Chesnay, France
Les Hôpitaux de Chartres
🇫🇷Le Coudray, France
Hôpital Privé de l'Estuaire
🇫🇷Le Havre, France
CHU Bicêtre
🇫🇷Le Kremlin-Bicêtre, France
Centre Hospitalier du Mans
🇫🇷Le Mans, France
CH de Lens
🇫🇷Lens, France
Institut Hospitalier Franco-Britannique
🇫🇷Levallois-Perret, France
Polyclinique de Limoges - Clinique Chenieux
🇫🇷Limoges, France
CHU de Limoges - Hôpital Dupuytren
🇫🇷Limoges, France
Groupe Hospitalier Bretagne Sud - Hôpital du Scorff
🇫🇷Lorient, France
Hôpital Nord
🇫🇷Marseille, France
HCL - Hôpital de la Croix Rousse
🇫🇷Lyon, France
Hôpital Privé Jean Mermoz
🇫🇷Lyon, France
Centre Hospitalier Layné
🇫🇷Mont-de-Marsan, France
Clinique de l'infirmerie Protestante
🇫🇷Lyon, France
Clinique de la Sauvegarde
🇫🇷Lyon, France
Institut Paoli Calmettes
🇫🇷Marseille, France
Centre Léon Bérard
🇫🇷Lyon, France
APHM - Hôpital de la Timone
🇫🇷Marseille, France
Centre de Cancérologe du Grand Montpellier
🇫🇷Montpellier, France
CH de Montelimar
🇫🇷Montélimar, France
Hôpital de la Milétrie
🇫🇷Poitiers, France
Clinique Francheville
🇫🇷Périgueux, France
Hôpitaux Drôme Nord - Centre Hospitalier Romans
🇫🇷Romans-sur-Isère, France
Hôpital Bichat
🇫🇷Paris, France
Hôpital Cochin
🇫🇷Paris, France
Hôpital Lariboisière
🇫🇷Paris, France
Institut Mutualiste Montsouris
🇫🇷Paris, France
Hôpital Nord Franche Comté
🇫🇷Montbeliard, France
CHRU de Montpellier - Hôpital Saint-Eloi
🇫🇷Montpellier, France
ICM - Val d'Aurelle
🇫🇷Montpellier, France
CHR Orléans
🇫🇷Orléans, France
CH Perpignan
🇫🇷Perpignan, France
HCL - Centre Hospitalier Lyon Sud
🇫🇷Pierre-Bénite, France
CH Annecy Genevois
🇫🇷Pringy, France
Centre Henri Becquerel
🇫🇷Rouen, France
Clinique Mathilde
🇫🇷Rouen, France
Hôpital de la Pitié Salpétrière
🇫🇷Paris, France
Groupe Hospitalier Diaconesses - Croix Saint-Simon
🇫🇷Paris, France
Centre Azuréen de Cancérologie
🇫🇷Mougins, France
Oracle - Centre d'Oncologie de Gentilly
🇫🇷Nancy, France
Hôpital Privé du Confluent
🇫🇷Nantes, France
Clinique Hartmann
🇫🇷Neuilly-sur-Seine, France
Centre Antoine Lacassagne
🇫🇷Nice, France
Institut de Cancérologie du Gard - ONCOGARD
🇫🇷Nîmes, France
Institut de Cancérologie du Gard
🇫🇷Nîmes, France
GH Saint Joseph
🇫🇷Paris, France
HEGP
🇫🇷Paris, France
CH Pau
🇫🇷Pau, France
CH René Dubos
🇫🇷Pontoise, France
Clinique de la Croix du Sud
🇫🇷Quint-Fonsegrives, France
HIA Begin
🇫🇷Saint-Mandé, France
Clinique Charcot
🇫🇷Sainte-Foy-lès-Lyon, France
Hôpitaux du Léman
🇫🇷Thonon-les-Bains, France
Centre Hospitalier de Troyes
🇫🇷Troyes, France
CH Jean Bernard
🇫🇷Valenciennes, France
Gustave Roussy
🇫🇷Villejuif, France
Institut Curie
🇫🇷Paris, France
Centre Catalan d'Oncologie
🇫🇷Perpignan, France
Centre Eugène Marquis
🇫🇷Rennes, France
Centre Hospitalier Privé Saint Grégoire
🇫🇷Saint Gregoire, France
CH Broussais
🇫🇷Saint-Malo, France
CHU Saint-Etienne - Pôle de Cancérologie
🇫🇷Saint-Priest-en-Jarez, France
Hôpital Privé de La Loire Saint-Etienne
🇫🇷Saint-Étienne, France
Centre Médicale Sainte Feyre Alfred Leune
🇫🇷Sainte-Feyre, France
CH Sens
🇫🇷Sens, France
CHR Metz-Thionville / Hôpital de Mercy
🇫🇷Thionville, France
Centre CARIO-HPCA
🇫🇷Plérin, France
Centre Frédéric Joliot
🇫🇷Rouen, France
Institut de Cancérologie Paris Nord
🇫🇷Sarcelles, France
Hôpital Foch
🇫🇷Suresnes, France
CHU Bretonneau
🇫🇷Tours, France
Clinique Pasteur - Oncosud
🇫🇷Toulouse, France
Institut Claudius Regaud
🇫🇷Toulouse, France
Centre Hospitalier Yves Le Foll
🇫🇷Saint Brieuc, France
Clinique Mutualiste de l'Estuaire
🇫🇷Saint Nazaire, France
Institut Curie - Site Saint Cloud
🇫🇷Saint-Cloud, France
ICANS - Institut de cancérologie Strasbourg Europe
🇫🇷Strasbourg, France
Clinique des Dentellières
🇫🇷Valenciennes, France
Hôpital d'Instruction des Armées Saint-Anne
🇫🇷Toulon, France
Clinique Pasteur - Groupe Oncorad Garonne
🇫🇷Toulouse, France
Institut de Cancérologie de Lorraine (ICL) - Centre Alexis Vautrin
🇫🇷Vandœuvre-lès-Nancy, France
Clinique du Mousseau (CMCO) - Ramsay Santé
🇫🇷Évry, France
Centre de Radiothérapie et d'Oncologie de Moyenne Garonne (CROMG)
🇫🇷Agen, France
Hôpital Privé d'Aix en Provence
🇫🇷Aix-en-provence, France
Centre Hospitalier Général d'Aix-en-Provence
🇫🇷Aix-en-Provence, France
CHU Amiens
🇫🇷Amiens, France
Clinique Victor PAUCHET
🇫🇷Amiens, France
Institut de Cancérologie de l'Ouest - ICO
🇫🇷Saint-Herblain, France