Changes in Nasal Patency With Changes in Posture, Temperature, Humidity and Nasal Patency Seen by Acoustic Rhinometry

Phase 4

Completed

• Conditions: Mucosal Congestion

• Registration Number: NCT00147888
• Lead Sponsor: University of Chicago

Brief Summary

To study nasal physiologic responses to changes in posture, temperatures, humidity and nasal patency with acoustic rhinometry.

Detailed Description

The purpose of this study was to utilize acoustic rhinometry to assess changes in nasal patency after alterations in posture, unilateral mechanical obstruction, temperature, and humidity.

Eight healthy adult volunteer subjects underwent acoustic rhinometry under the following conditions: 1) upright, sitting position (control), 2) supine position, 3) left lateral recumbent position, 4) one nostril mechanically blocked, 5) icepack on neck, 6) drinking cold water, 7) drinking hot water, 8) nasal nebulizer, 9)oxymetazoline decongestant.

Changes in nasal cavity volumes were detected by acoustic rhinometry after alterations in posture, unilateral mechanical obstruction, temperature, and humidity. Nebulizer treatment and hot water ingestion caused a significant decrease in nasal volume. The nose was able to adapt to environmental and physiological changes in order to maintain a consistent total nasal volume.

Study Timeline

• Study Start: 2004-03
• Study First Submitted: 2005-09-02
• Study First Submitted QC: 2005-09-06
• Study First Posted: 2005-09-07
• Primary Completion: 2006-12
• Study Completion: 2006-12
• Status Verified: 2013-09
• Last Update Submitted: 2013-09-04
• Last Update Posted: 2013-09-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 15

Inclusion Criteria

• Healthy volunteers, 18-58 years old

Exclusion Criteria

• Any nasal symptoms in the last 3 weeks
• Marked septal deviation/polyposis/infection
• Any history of allergy, asthma or immunodeficiency
• Any systemic condition or infection (e.g., hypertension/diabetes/heart, liver, thyroid or kidney disease
• Any spine or neck condition that would not allow normal postures
• Pregnancy

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
Changes in nasal patency	5-10 minutes

Secondary Outcome Measures

Name	Time	Method
Nasal volume	5-10 minutes

Trial Locations

Locations (1)

The University of Chicago; 🇺🇸 Chicago, Illinois, United States