Comparison of Cryotherapy and Peeling Agent in the Treatment of Common Warts

Not Applicable

Completed

• Conditions: Warts
• Interventions: Drug: CRYOTHERAPY; Drug: Tricholoracetic acid

• Registration Number: NCT05712811
• Lead Sponsor: Combined Military Hospital Abbottabad

Brief Summary

Objective: To compare the efficacy of cryotherapy using liquid nitrogen (cryoget method) versus trichloroacetic acid 90% (applicator method) in treatment of common warts.

Study Design: Randomized Control Trial. Place And Duration of Study: Department of Dermatology, CMH Abbottabad from Jun 2022 to Nov, 2022.

Detailed Description

A total of 60 patients were enrolled in this investigation by non-probability consecutive sampling technique. Sample size was calculated using WHO sample size calculator and patients were randomized into two equal groups, A and B, each comprising of 30 patients through lottery method. Patients with common warts such as hard lesions, raised lumps with rough surfaces at the back of their fingers, around nails and palm of their hands between the ages of 18 and 60 were included, whereas those with genital warts, cardiac, hepatic, renal, or hypercholesterolemia were excluded.

Study Timeline

• Study Start: 2022-06-01
• Primary Completion: 2022-11-30
• Study Completion: 2022-11-30
• Status Verified: 2023-01
• Study First Submitted: 2023-01-18
• Study First Submitted QC: 2023-01-26
• Last Update Submitted: 2023-01-26
• Study First Posted: 2023-02-06
• Last Update Posted: 2023-02-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Patient presented with common warts in dermatology opd

Exclusion Criteria

• • Patients with warts on toes and tip of fingers

  • genital warts
  • cardiac, hepatic and renal disease
  • hypercholesterolemia
  • hypersensitivity reactions

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Group A cryotherapy	CRYOTHERAPY	Cryotherapy Group A had their warts treated once every two weeks for a total of twelve weeks, with liquid nitrogen using cryoget method for 10 to 15 seconds on each lesion (depending on size, until a narrow white rim of around 1 mm developed around it).
Group B Topical TCA 90%	Tricholoracetic acid	Topical TCA 90 % Warts in Group B were treated with liquid TCA 90% by an applicator every two weeks for a total of twelve weeks. After 20 minutes, patients were instructed to remove the solution by washing their warts with water or regular saline

Primary Outcome Measures

Name	Time	Method
Comparison of cryotherapy and Tricholoracetic acid 90% in treatment of common warts	12 weeks	Outcome was determined at the end of third month and the patients were labelled as cured and the efficacy was labelled as "Yes" in cases with absence of all the lesions. After twelve weeks of therapy, individuals with persistent warts were regarded as cases of treatment failure and efficacy was labelled as "No".

Trial Locations

Locations (1)

Cmh abbottabad; 🇵🇰 Abbottābād, Kpk, Pakistan