Evaluation of the effect of 5% hypertonic saline nebulization on inflammatory factors and recovery in patients with severe pneumonia caused by covid 19

Phase 1

Recruiting

Conditions: The effect of 5% hypertonic saline on blood levels of inflammatory factors in patients with severe pneumonia caused by covid 19.
Other viral pneumonia
J12.8

Registration Number: IRCT20120216009045N4

Lead Sponsor: Tehran University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 40

Inclusion Criteria

Patient with Covid-19 coronavirus (confirmation of diagnosis by positive PCR test)
Severe pneumonia due to COVID-19
Age 70 - 18 years
Conscious consent of the patient or her guardian in cases that the patient is not conscious.

Exclusion Criteria

Receiving interleukin production inhibitors such as Octemra
Patients with a history of HIV + or any history of immunodeficiency
Patient with active bacterial pneumonia
Primary or metastatic lung cancer
History of any cancer or malignancy
Chronic lung diseases include: pulmonary fibrosis, bronchiectasis, asthma
smoking
Previous thoracic and lung surgery
Patients with hypernatremia
Intubated patients

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Interleukin 6. Timepoint: While hospitalized in the ICU for 5 days, before and after of intervention. Method of measurement: Samples containing the biomarkers are transferred to a reference laboratory in an EDTA-containing test tube, and centrifuged at 3,000 rpm for 15 minutes. The resulting plasma for measuring IL-6, TNF-a markers is stored by the researcher at minus 80 ° C. Quantitative determination is done by the quantitative sandwich enzyme immunoassay method by Bendermed commercial kits.;Measurement of serum TNF_a before and after the intervention. Timepoint: During 5 days of admission in the ICU. Method of measurement: Samples containing the biomarkers are transferred to a reference laboratory in an EDTA-containing test tube, and centrifuged at 3,000 rpm for 15 minutes. The resulting plasma for measuring IL-6, TNF-a markers is stored by the researcher at minus 80 ° C. Quantitative determination is done by the quantitative sandwich enzyme immunoassay method by Bendermed commercial kits.

Secondary Outcome Measures