Evaluation of Sevoflurane in Chronic Obstructive Pulmonary Disease Exacerbation in Intensive Care Unit: A Comparative Prospective Study
Overview
- Phase
- Not Applicable
- Intervention
- Sevoflurane
- Conditions
- COPD Exacerbation
- Sponsor
- University Hospital, Montpellier
- Enrollment
- 16
- Locations
- 1
- Primary Endpoint
- Evolution of airway resistance before and after sevoflurane in COPD patients
- Status
- Terminated
- Last Updated
- 4 years ago
Overview
Brief Summary
Prospective, open-label, single-center, study to investigate the effect of sevoflurane sedation compared to a propofol-controlled arm during COPD exacerbation requiring invasive mechanical ventilation in ICU.
Primary outcome measure:
Evolution of airway resistance before and after sevoflurane in COPD patients,
Secondary outcomes measures:
Respiratory mechanics (Maximum pressure, PEEPi and PEEPtot, trapped volume), Gas exchange by the help of blood gases, The heterogeneity of alveolar ventilation by electro-impedancemetry, Evolution of pulmonary inflammation, Trophicity and contractility of the diaphragm,
Investigators
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Arms & Interventions
Sevoflurane group
Intervention: Sevoflurane
Sevoflurane group
Intervention: Propofol
Propofol group
Intervention: Propofol
Outcomes
Primary Outcomes
Evolution of airway resistance before and after sevoflurane in COPD patients
Time Frame: Hour 48
Total airway resistance will be measured using the ventilator by setting a 5s inspiratory pause and to measure the sum of (Pmax-P1)/Flow + (P1-Pplat)/Flow. The mechanical ventilation setting will be standardised during the study period and will be similar between the two groups.
Secondary Outcomes
- Maximum pressure(Evolution between Hour 0 and Hour 48)
- PEEPi(Evolution between Hour 0 and Hour 48)
- PEEPtot(Evolution between Hour 0 and Hour 48)
- Heterogeneity of alveolar ventilation by electro-impedancemetry(Evolution between Hour 0 and Hour 48)
- Thickness of the diaphragm measured by ultrasound(Evolution between Hour 0 and Hour 48)
- Trapped volume(Evolution between Hour 0 and Hour 48)
- Gas exchange by the help of blood gases(Evolution between Hour 0 and Hour 48)
- Proinflammatory cytokines (IL1, IL6, TNFalpha) and sRAGE measurements in miniBroncho-Alveolar lavages(Evolution between Hour 0 and Hour 48)