Comparing efficacy of ECT with and without concurrent sodium valproate therapy in manic patients

Not Applicable

• Conditions: Manic episode of bipolar disorder.; Bipolar affective disorder, current episode manic without psychotic symptoms, Bipolar affective disorder, current episode manic with psychotic symptoms; F31.1 and

• Registration Number: IRCT138901161743N3
• Lead Sponsor: Research center for behavioral disorders and substance abuse, Hamadan University of Medical Science

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 February 2018

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 42

Inclusion Criteria

obtaining informed consent, Diagnosis of bipolar I disorder, manic episode, must be confirmed according to DSM IV-TR criteria, Manic episode refractory to pharmacotherapy, receiving therapeutic doses of valproate before ECT for at least 5 days, Serum levels of valproate =50 µg/ml, Administration of ECT by attending psychiatrist, age 18-60 years
Exclusion criteria: Uncontrolled physical condition, Pregnant and nursing women, LFT: 3 fold greater than upper normal limits, receiving other anticonvulsant medications, History of epilepsy

Exclusion Criteria

Not provided

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Improvement rate of mania. Timepoint: after second, fourth, sixth and at the end of sessions of ECT. Method of measurement: CGI and YMRS.