Metabolomic Fingerprint of Severe Obesity is Dynamically Affected by Bariatric Surgery in a Procedure-dependent Manner
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 106
- 主要终点
- compare the NMR metabolic fingerprint as assessed in serum samples of severely obese patients with that of normal-weight control subjects
研究概览
简要总结
Background: Obesity is associated with multiple diseases. Bariatric surgery is the most effective therapy for severe obesity that cannot only reduce body weight but also obesity-associated morbidity.
Objective: The metabolic alterations associated with obesity and respective changes after bariatric surgery are incompletely understood.
Design: In the longitudinal observational study, the investigator applied a 1H-NMR-based global, untargeted metabolomics strategy on human serum samples that were collected before and repeatedly up to one year after distinct bariatric procedures (sleeve gastrectomy, proximal and distal Roux-en Y gastric bypass; RYGB). For comparison, the investigator also analyzed serum samples from normal-weight and less obesity obese subjects that were matched for 1-year postoperative BMI values of the surgical groups.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •BMI >/=35 kg/m2
- •at least 2 years of unsuccessful conservative weight loss attempts
排除标准
- •< 18 years of age
- •BMI < 35 kg/m2
- •informed consent was not signed by the patient
结局指标
主要结局
compare the NMR metabolic fingerprint as assessed in serum samples of severely obese patients with that of normal-weight control subjects
时间窗: pre operative
follow up changes in the metabolic fingerprint over one year after 3 distinct bariatric procedures
时间窗: pre operative, 3-, 6-, 9- and 12 months post operative
compare the metabolic fingerprints established one year after the different surgeries with those of BMI-matched and normal-weight control subjects
时间窗: 12 months post operative
次要结局
未报告次要终点