Metabolomic Fingerprint After Bariatric Surgery
- Conditions
- Obesity
- Registration Number
- NCT02480322
- Lead Sponsor
- eSwiss Medical & Surgical Center
- Brief Summary
Background: Obesity is associated with multiple diseases. Bariatric surgery is the most effective therapy for severe obesity that cannot only reduce body weight but also obesity-associated morbidity.
Objective: The metabolic alterations associated with obesity and respective changes after bariatric surgery are incompletely understood.
Design: In the longitudinal observational study, the investigator applied a 1H-NMR-based global, untargeted metabolomics strategy on human serum samples that were collected before and repeatedly up to one year after distinct bariatric procedures (sleeve gastrectomy, proximal and distal Roux-en Y gastric bypass; RYGB). For comparison, the investigator also analyzed serum samples from normal-weight and less obesity obese subjects that were matched for 1-year postoperative BMI values of the surgical groups.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 106
- BMI >/=35 kg/m2
- at least 2 years of unsuccessful conservative weight loss attempts
- < 18 years of age
- BMI < 35 kg/m2
- informed consent was not signed by the patient
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method compare the NMR metabolic fingerprint as assessed in serum samples of severely obese patients with that of normal-weight control subjects pre operative follow up changes in the metabolic fingerprint over one year after 3 distinct bariatric procedures pre operative, 3-, 6-, 9- and 12 months post operative compare the metabolic fingerprints established one year after the different surgeries with those of BMI-matched and normal-weight control subjects 12 months post operative
- Secondary Outcome Measures
Name Time Method
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