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Clinical Trials/NCT01785134
NCT01785134
Completed
Not Applicable

Metabolic Effects of Different Surgical Methods to Treat Obesity

Karolinska Institutet4 sites in 1 country81 target enrollmentMay 2006
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ConditionsObesityType 2 DiabetesInsulin Sensitivity

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Obesity
Sponsor
Karolinska Institutet
Enrollment
81
Locations
4
Primary Endpoint
Insulin Sensitivity at 2 Years
Status
Completed
Last Updated
11 years ago
OverviewInvestigatorsEligibility CriteriaOutcomesSitesSimilar Trials

Overview

Brief Summary

Obese patients have an increased risk for developing severe metabolic disorders. This risk can only partly be reduced by weight reduction. The investigators have in a pilot study investigated if removal of abdominal fat (visceral) in addition to weight loss has additional beneficial effects on the metabolic profile and weight loss. This study aims to further investigate if removal of abdominal fat (major omentum) leads to beneficial metabolic effects.

Registry
clinicaltrials.gov
Start Date
May 2006
End Date
December 2011
Last Updated
11 years ago
Study Type
Interventional
Study Design
Parallel
Sex
Female

Investigators

Responsible Party
Principal Investigator
Principal Investigator

Erik Näslund

Professor, MD, PhD

Karolinska Institutet

Eligibility Criteria

Inclusion Criteria

  • •Body mass index over 40 kg/m2
  • •Body mass index over 35 kg/m2 with obesity associated co-morbidities such as type 2 diabetes and/or additional cardiovascular risk factors -

Exclusion Criteria

  • Not provided

Outcomes

Primary Outcomes

Insulin Sensitivity at 2 Years

Time Frame: 2 years postoperative

Insulin sensitivity measured by hyperinsulinemic euglycemic clamp

Secondary Outcomes

  • Body Composition at Two Years(2 years postoperative)
  • Blood Pressure at 2 Years(2 years postoperative)
  • Blood Lipids(2 years postoperative)
  • Body Mass Index at 2 Years(2 years postoperative)

Study Sites (4)

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