Plasmalyte and Hartmann’s solution for cardiopulmonary pump prime during cardiopulmonary bypass

Phase 4

Completed

• Conditions: Cardiopulmonary bypass; Cardiac surgery; Cardiovascular - Coronary heart disease; Anaesthesiology - Anaesthetics; Surgery - Surgical techniques

• Registration Number: ACTRN12612000022864
• Lead Sponsor: Austin Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2012-01-06
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

1. Adult patient (age > 18years)
2. Elective CABG or valve surgery
3. Requirements for cardiopulmonary bypass

Exclusion Criteria

1. Decline to participate
2. Pregnancy
3. Abnormal pre-operative venous plasma bicarbonate concentration (< 22 mmol/L or > 27 mmol/L)
4. Hypercapnoeic respiratory failure
5. Chronic renal impairment (creatinine > 150 micromol/L)
6. Known diabetes mellitus or HbA1c > 10% (elevated blood acetate concentrations have been reported in patients with type 2 diabetes mellitus)
7. Chronic liver disease
8. Anaemia (haemoglobin level <10 g/dL)
9. Morbid obesity (BMI > 35kg/m2)
10. Known allergic reaction to study solutions

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Standard base deficit[Blood sampling was performed at 5 time points:<br>1. T1: baseline immediately prior to CPB <br>2. T2: Five minutes after achieving full flows on CPB, prior to placement of aortic cross clamp<br>3. T3: Fifteen minutes after achieving full flows on CPB<br>4. T4: Thirty minutes after achieving full flows on CPB<br>5. T5: On rewarming, just prior to separation from CPB]