Impact of Lidocaine on Anesthetic Depth During Rapid Sequence Induction
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 76
- Locations
- 1
- Primary Endpoint
- BIS changes after lidocaine administration in rapid sequence induction
Study Overview
Brief Summary
Lidocaine has been shown to blunt the cardiovascular response to endotracheal intubation. The incidence of hypertension, tachycardia and dysrhythmias due to laryngoscopy may be increased in patients that receive rapid sequence induction and intubation, where opioids are spared and intravenous anesthetic agents are not titrated step by step. Our hypothesis was that lidocaine when administered intravenously in patients who undergo rapid sequence induction may not only blunt the hemodynamic response to intubation, but may also increase the anesthetic depth (as assessed by BIS), thus further reducing the possibility of hypertension, arrhythmias and also awareness.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Masking
- Triple (Participant, Investigator, Outcomes Assessor)
Eligibility Criteria
- Ages
- 20 Years to 70 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •reason for rapid sequence induction (emergency, reflux),
- •ASA I-II,
- •no antihypertensive drugs,
- •no antiarrhythmic drugs
- •Exclusion Criteria :
Exclusion Criteria
- Not provided
Arms & Interventions
lidocaine
Intervention: Lidocaine (Drug)
normal saline
Intervention: Placebo (Drug)
Outcomes
Primary Outcomes
BIS changes after lidocaine administration in rapid sequence induction
Time Frame: change from baseline in BIS values during 10 minutes
Secondary Outcomes
- change in blood pressure(change from baseline in blood pressure during 10 minutes)
- change in Heart rate(change from baseline in heart rate durng 10 minutes)