Military Aggression Regulation Study

Completed

Conditions: agressieregulatie problematiek
aggression
anger
10021563

Registration Number: NL-OMON39980

Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 100

Inclusion Criteria

For participants with impulsive aggression, the following inclusion criteria:
- Soldiers and veterans (men) who participated in a military deployment (minimum 4 months)
- Age between 18 and 50 years
- Presence of problems with aggression as evidenced by either (I): the A1 or A2 criterion of the research diagnostic criteria for impulsive aggression (Coccaro, 2012), or (II) evidence for problems with pent-up anger as revealed by answers to the screening questionnaire.
- Written informed consent; For control participants, the following inclusion criteria:
- Healthy men
- Age between 18 and 50 years
- Written informed consent
- No (current) DSM-IV Axis-I disorder
- No evidence of problems with aggression

Exclusion Criteria

- Alcohol / substance abuse and / or dependence
- Severe neurological diseases (eg Parkinson's disease, stroke, MS);Exclusion for MRI procedure:
- Claustrophobia, pacemaker (or other implants), or metal objects in the body causing an MRI scan is not possible.
- Current use of psychotropic drugs (benzodiazepines, antidepressants, antipsychotics, anticonvulsants)

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Differences in amygdala and prefrontal cortex activity, differences in startle<br /><br>response, differences in blood parameters as neuropeptide Y, vasopressin and<br /><br>testosterone, differences in performance on neuropsychological tasks between<br /><br>veterans with aggression regulation problems and healthy control participants. </p><br>

Secondary Outcome Measures