IRCT20100107003014N26招募中1 期
Comparison the efficacy of adding levofloxacin and colistin inhalation form to basic regimen of colistin and meropenem in treatment of ventilator associated pneumonia (VAP) caused by multidrug resistant pathogens: a double-blind randomized clinical trial
适应症
试验速览
- 阶段
- 1 期
- 状态
- 招募中
- 入组人数
- 70
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 years 至 80 years（—）
- 性别
- All
入选标准
- •Age older than 18 years and less than 80 years
- •Mechanical ventilation for more than 48 hours
- •Pneumonia diagnosis based on the 2016 guidelines of the Infectious Diseases Society of America (IDSA)
- •CPIS score above 6
- •Positive culture of sputum sample and growth of gram-negative bacteria resistant to treatment (MDR) (Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacteriaceae, etc.)
排除标准
- •Pregnancy or breastfeeding
- •History of allergy to any of the drugs Colistin, Levofloxacin and Meropenem
- •Acute respiratory distress syndrome
- •Pulmonary tuberculosis disease under treatment
- •Cystic fibrosis disease
- •Major interaction of other drugs used by the patient with levofloxacin, colistin or meropenem
- •Baseline creatinine clearance less than 15 mL/min
- •History of receiving antibiotics effective against MDR pathogens during hospitalization
- •Presence of pneumonia before intubation
研究者
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