IRCT20100107003014N26
Recruiting
Phase 1
Comparison the efficacy of adding levofloxacin and colistin inhalation form to basic regimen of colistin and meropenem in treatment of ventilator associated pneumonia (VAP) caused by multidrug resistant pathogens: a double-blind randomized clinical trial
Overview
- Phase
- Phase 1
- Intervention
- Not specified
- Conditions
- Ventilator associated pneumonia (VAP) caused by multidrug resistant pathogens.
- Sponsor
- Mazandaran University of Medical Sciences
- Enrollment
- 70
- Status
- Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Age older than 18 years and less than 80 years
- •Mechanical ventilation for more than 48 hours
- •Pneumonia diagnosis based on the 2016 guidelines of the Infectious Diseases Society of America (IDSA)
- •CPIS score above 6
- •Positive culture of sputum sample and growth of gram\-negative bacteria resistant to treatment (MDR) (Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacteriaceae, etc.)
Exclusion Criteria
- •Pregnancy or breastfeeding
- •History of allergy to any of the drugs Colistin, Levofloxacin and Meropenem
- •Acute respiratory distress syndrome
- •Pulmonary tuberculosis disease under treatment
- •Cystic fibrosis disease
- •Major interaction of other drugs used by the patient with levofloxacin, colistin or meropenem
- •Baseline creatinine clearance less than 15 mL/min
- •History of receiving antibiotics effective against MDR pathogens during hospitalization
- •Presence of pneumonia before intubation
Outcomes
Primary Outcomes
Not specified
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