Effect of pre-operative pain treatment by means of duloxetine on postoperative outcome after total hip or knee arthroplasty- The DOA study

• Conditions: osteoarthritis; central sensitization; peripheral sensitization; residual painDutch: artrose; centrale sensitisatie; perifere sensitisatie; residuele pijn

• Registration Number: NL-OMON25835
• Lead Sponsor: niversity Medical Center Groningen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 28 February 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 118

Inclusion Criteria

Primary hip or knee osteoarthitis, age above 18 years and a neuropathic pain profile

Exclusion Criteria

Surgical hip or knee procedure in previous year, hip or knee arthroscopy or injection past 3 months, unstable other medical condition, cognitive of neurological disorder or peripheral nerve injury, previous exposure to duloxetine

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Degree of pain relief 6 months after total hip or knee arthroplasty

Secondary Outcome Measures

Name	Time	Method
Degree of pain relief at other timepoints, specific neuropathic pain symptoms, functional improvement, physical activity, anxiety and depressive symptoms, quality of life and pain catastrophizing