Forceps Biopsy Versus Cryo-biopsy in the Diagnosis of Lung Cancer

Not Applicable

Completed

• Conditions: Lung Cancer
• Interventions: Procedure: bronchoscpe

• Registration Number: NCT05151419
• Lead Sponsor: Nashwa Ahmed Mohammad amin

Brief Summary

This study was comprised of 30 patients who were scheduled for a diagnostic bronchoscopy due to a suspicion of lung cancer in order to obtain tissue samples for a final diagnosis , four biopsies were taken by each of cryobiopsy and forceps biopsy , to evaluate and compare the diagnostic yield of endobronchial cryobiopsy and forceps biopsy in the diagnosis of lung cancer .

Detailed Description

Diagnostic bronchoscopic interventions are used to evaluate and tissue sample from endobronchial lesions utilising variety of devices that can be delivered through the operative channel of a fibrio-optic bronchoscope.

All of the procedures were carried out with 2% lidocaine instillation and midazolam IV sedation All patients signed a written informed consent form for bronchoscopy and tissue sampling with forceps and a cryoprobe.between August 2020 and June 2021. All interventions were performed in the bronchoscopy unit of the Chest Medicine Department at Benha university Data were collected, revised, coded and entered to the Statistical Package for Social Science (IBM SPSS) version 23. The quantitative data with parametric distribution were presented as mean, standard deviations and ranges.

Study Timeline

• Study Start: 2020-07-21
• Primary Completion: 2021-06-05
• Study Completion: 2021-09-16
• Status Verified: 2021-11
• Study First Submitted: 2021-11-14
• Study First Submitted QC: 2021-11-27
• Last Update Submitted: 2021-11-27
• Study First Posted: 2021-12-09
• Last Update Posted: 2021-12-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• severe uncorrected hypoxemia despite supplemental oxygen treatment
• unstable angina
• uncontrolled arrhythmias,
• severe hypercarbia,
• unstable cervical spine.
• Coagulopathy that cannot be reversed
• Chronic obstructive pulmonary disease (COPD) exacerbation
• Severe Illness
• old age
• malnutrition
• Patient who refused to have a bronchoscopy performed

Exclusion Criteria

Patients' histories, including age, sex, and smoking status, were documented for all participants in the trial Clinical examination and medical history Complete blood count, serum creatinine, liver enzymes, INR, bleeding time, and clotting time are all routine laboratory tests Plain chest X-ray and chest computed tomography were used in the radiological workup* Arterial blood gas on room air. bronchoscopy and biopsy taking with forceps and cryobiopsy

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
bronchoscope ,forceps,cryo-biopsy	bronchoscpe	biopies were taken from the lung mass using forceps and cryo-biopsy to evalute diagnostic yield of cryo-biosy versus forceps in the diagnosis of lung cancer

Primary Outcome Measures

Name	Time	Method
Comparative study between Endobronchial Forceps-Biopsy and Cryo-Biopsy in the Diagnosis of bronchogenic carcinoma	comprative , week 40	The comparison between groups regarding qualitative data was done by using Chi-square test and/or Fisher exact test when the expected count in any cell found less than 5.at week 40

Trial Locations

Locations (1)

Benha University Hospital- Chest Department; 🇪🇬 Cairo, Egypt