Muscle metabolism during exercise in children with Juvenile Dermatomyositis and the relationship with inflammatio

Completed

Conditions: Juvenile Dermatomyositis (JDM)
muscle arthritis
10003816
10028393

Registration Number: NL-OMON32652

Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 10

Inclusion Criteria

Diagnosed juvenile Dermatomyositis, between 12- 18 years of age, clinical remission has been diagnosed by the attending physician, signed informed consent by patient and parents/ legal representatives.
Inclusion criteria healthy subjects:
healthy, active lifestyle, signed informed consent by subject and parents/ legal representatives

Exclusion Criteria

Diagnosed polymyositis or myositis with MCTD, active myositis, age < 12 years and >18 years, no informed consent
Exclusion criteria healthy subjects:
history of muscle disease, chronic medication usage, underlying auto-immune disease (e.g. JIA, SLE, MCTD), no informed consent

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>In 5 patients with JDM (and the 5 healthy controls) there will be studied<br /><br>whether there are difference demonstrable concerning the muscle energetics in<br /><br>the proximal leg muscles during a recumbent bicycle-exercise test in a MR<br /><br>scanner (using 31P MRS) as a measure for an efficient metabolism.<br /><br><br /><br>The following parameters will be determined:<br /><br>(i) Phosphocreatin/ anorganic Phosphate (PCr/Pi) ratio at different levels of<br /><br>exercise load<br /><br>(ii) Glycolytic intermediary metabolite concentration (mono-phosphorylised<br /><br>glucose)<br /><br>during different levels of exercise load<br /><br>(iii) Acidity (pH value) at different levels of exercise load<br /><br>(iv) Energy usage (ATP turnover; mm/s) during different levels of exercise load<br /><br>(v) ATP buffer (PCr) re-synthesis speed during recovery after exercise</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The ratios between the measured VO2 piek and CO2 piek are determined in<br /><br>relation to maximal power (Wmax), to describe a unit of measure for the<br /><br>so-called mechanical efficiency of the muscles.</p><br>