Efficacy and Safety of the Regulatory Polypeptides in Patients With Peripheral Atherosclerosis.
- Conditions
- Peripheral Arterial Occlusive Disease
- Interventions
- Drug: PolypeptidesOther: Routine conservative treatmentDevice: Femoral-popliteal bypass grafting with a synthetic graft above the knee
- Registration Number
- NCT05933720
- Lead Sponsor
- Ryazan State Medical University
- Brief Summary
The study is aimed at assessing the role of the activity of markers of endothelial dysfunction (cytotoxic malonic aldehyde (MDA), angiotensin II, endothelial nitric oxide synthase (NO), endothelin-1, prostacyclin) in the systemic circulation in patients with lower extremity atherosclerotic arterial occlusive disease undergoing open reconstructive interventions.
- Detailed Description
The study will include 120 patients of similar age, gender, and ethnicity, they will be divided into four groups: Group I: 30 patients with lower extremity atherosclerotic arterial occlusive disease, stage IIA-IIB of the disease according to the Fontaine-Pokrovsky classification, receiving conservative therapy; Group II: 30 patients with lower extremity atherosclerotic arterial occlusive disease, stage IIA-IIB of the disease according to the Fontaine-Pokrovsky classification, receiving conservative therapy, including the drug based on vascular polypeptides Slavinorm®; Group III: 30 patients with lower extremity atherosclerotic arterial occlusive disease, stageIII-IV of the disease according to the Fontaine-Pokrovsky classification, receiving conservative therapy in combination with surgical methods of treatment (femoral-popliteal bypass grafting with a synthetic graft above the knee); Group IV: 30 patients with lower extremity atherosclerotic arterial occlusive disease, stage III-IV of the disease according to the Fontaine-Pokrovsky classification, receiving conservative therapy, including the drug based on vascular polypeptides Slavinorm®, in combination with surgical methods of treatment (femoral-popliteal bypass grafting with a synthetic graft above the knee).
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 120
men or women over 18 years of age with lower extremity atherosclerotic arterial occlusive disease, confirmed with instrumental work-up methods (ultrasonography or angiography).
men or women under 18 years of age; history of anaphylaxis; hypersensitivity to any of the components that make up the drug Slavinorm®, and proteins of animal origin; absolute and relative contraindications to the treadmill test; failure to walk at a minimum speed of 3.2 km/h (2 mph) at a minimum treadmill angle for at least 2 minutes during the stress test during the screening phase; depression of the ST segment more than 1 mm in one or more standard leads on the electrocardiogram; peripheral artery disease not associated with atherosclerosis; patients who underwent reconstructive surgery or invasive interventions on the arteries of the lower extremities in history without a clinic of intermittent claudication; angina pectoris III-IV functional class (FC) according to the CCS classification; body mass index >35 kg/m2; acute or chronic renal (creatinine clearance less than 30 ml / min) and / or liver failure [aspartate aminotransferase (AST), alanine aminotransferase (ALT) > 3 times the upper limit of normal]; chronic heart failure III-IV FC according to NYHA; acute coronary syndrome within 6 months. before the start of the screening period; any clinically significant condition or comorbidity that, in the opinion of the Investigator, would preclude the patient from participating in the study.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Patients who undergo treatment with polypeptides Polypeptides The patients who undergo treatment with a complex of polypeptides isolated from the vessels of cattle is administered in / m, adults 1 vial (5 mg) 1 time / day 2 times a week. The course of treatment is 10 injections. Patients who undergo routine conservative treatment Routine conservative treatment The patients who undergo routine conservative treatment for peripheral atherosclerotic occlusive disease as per clinical guidelines Patients who undergo femoral-popliteal bypass grafting and treatment with polypeptides Polypeptides Patients who undergo the surgical method of treatment i.e. femoral-popliteal bypass grafting with a synthetic graft above the knee with following treatment with a complex of polypeptides isolated from the vessels of cattle is administered in / m, adults 1 vial (5 mg) 1 time / day 2 times a week. The course of treatment is 10 injections. Patients who undergo femoral-popliteal bypass with a synthetic graft above the knee Femoral-popliteal bypass grafting with a synthetic graft above the knee Patients who undergo the surgical method of treatment i.e. femoral-popliteal bypass grafting with a synthetic graft above the knee and routine conservative treatment as per clinical guidelines Patients who undergo femoral-popliteal bypass with a synthetic graft above the knee Routine conservative treatment Patients who undergo the surgical method of treatment i.e. femoral-popliteal bypass grafting with a synthetic graft above the knee and routine conservative treatment as per clinical guidelines Patients who undergo femoral-popliteal bypass grafting and treatment with polypeptides Femoral-popliteal bypass grafting with a synthetic graft above the knee Patients who undergo the surgical method of treatment i.e. femoral-popliteal bypass grafting with a synthetic graft above the knee with following treatment with a complex of polypeptides isolated from the vessels of cattle is administered in / m, adults 1 vial (5 mg) 1 time / day 2 times a week. The course of treatment is 10 injections.
- Primary Outcome Measures
Name Time Method disease progression 1 year The rate of the disease progression
restenosis 1 year Restenosis rate
Lower artery or bypass graft thrombosis 1 year The rate of the Lower artery or bypass graft thrombosis
- Secondary Outcome Measures
Name Time Method changes in pain-free walking distance 1 year Changes in the parameter of pain-free walking distance (in meters)
limb loss 1 year Limb loss rate
changes in ankle-brachial index 1 year Changes in the parameter of ankle-brachial index measured at rest
Trial Locations
- Locations (1)
RyazanSMU
🇷🇺Ryazan, Russian Federation