To compare hemodynamic response in laparoscopic surgeries after administering different doses of oral clonidine.
Phase 4
- Conditions
- Health Condition 1: K800- Calculus of gallbladder with acutecholecystitis
- Registration Number
- CTRI/2021/06/034319
- Lead Sponsor
- Kasturba medical college
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1.ASA grades I or II
2.Either gender
3.Adult patients aged > 18 years and < 60 years
4.Scheduled for laparoscopic cholecystectomy
Exclusion Criteria
1.Patients not willing to give consent
2.Patients allergic to clonidine
3.Patient with concomitant use of monoamine oxidase inhibitors, tricyclic antidepressants or opioids
4.Pregnant females
5.Patients who are chronic hypotensive.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To compare and evaluate pneumoperitoneum induced haemodynamic changes after administering oral clonidine at different doses as premedication with respect to the following: <br/ ><br>1) Heart Rate (HR) <br/ ><br>2) Systolic Bp (SBP) <br/ ><br>3) Diastolic BP (DBP) <br/ ><br>4) Mean arterial blood pressure (MAP) <br/ ><br>5) End tidal cabon di-oxide (EtCo2) <br/ ><br>6) EntropyTimepoint: Vitals measured at various time interval: <br/ ><br> <br/ ><br>Baseline <br/ ><br>After premedication <br/ ><br>Before induction <br/ ><br>2 minutes after Endotracheal tube intubation <br/ ><br>time in minutes after insufflation (AI): <br/ ><br>AI 1 <br/ ><br>AI 5 <br/ ><br>AI 15 <br/ ><br>AI 30 <br/ ><br>AI 45 <br/ ><br>AI 60 <br/ ><br>Exsufflation <br/ ><br>After extubation <br/ ><br>
- Secondary Outcome Measures
Name Time Method 1.Preoperative anxiety scores <br/ ><br>2.Use of additional opioids intraoperatively <br/ ><br>3.Post-operative nausea, vomiting and shivering in the first 2 hours, postoperatively <br/ ><br>4.To compare post-operative sedation in the first 2 hours <br/ ><br>5.Awareness using entropy <br/ ><br>Timepoint: number of episodes of sedation and post operative nausea and vomiting for 2 hours post surgery