Comparison of nalbuphine and dexmedetomidine for blunting intubation response

Not Applicable

• Conditions: Health Condition 1: null- Patients undergoing elective surgery under general anaesthesia and requiring endotracheal intubation

• Registration Number: CTRI/2018/03/012707
• Lead Sponsor: niversity College of Medical Sciences and Guru Teg Bahadur Hospital Delhi

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 24 November 2021

Recruitment & Eligibility

• Status: Open to Recruitment
• Sex: Not specified
• Target Recruitment: 80

Inclusion Criteria

1 Patients undergoing elective surgery under general anaesthesia and requiring endotracheal intubation

2 Patients belonging to American Society of Anesthesiologist (ASA) grade I and II

3 Patients of either gender

4 Patients between 18-60 years of age

5 Patients between 40-70 kg of weight

6 Modified Mallampati Grade I and II

Exclusion Criteria

1 Patientâ??s refusal

2 Patients with history of allergy to opioids, difficult intubation or sleep apnea

3 Patients with history of cardiovascular, cerebral, renal, hepatic, bronchospastic or endocrine disease or psychiatric disorder.

4 Patients on anti hypertensives, hypnotic or narcotic analgesics

5 Patients with anticipated difficult airway (Modified Mallampatti grade III and IV, thyromental distance <6 cm, mouth opening <3 cm, cervical instability)

6 Full stomach patients, pregnant and lactating females.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change in heart rate (HR) and systolic blood pressure (SBP)Timepoint: Tb: Baseline in OT <br/ ><br>Td: After test drug administration over 10 minutes <br/ ><br>Tp: After propofol administration <br/ ><br>Tv: 3 minutes after vecuronium administration <br/ ><br>T0: At the time of intubation <br/ ><br>T1: 1 minute after endotracheal intubation <br/ ><br>T3: 3 minutes after endotracheal intubation <br/ ><br>T5: 5 minutes after endotracheal intubation <br/ ><br>T10: 10 minutes after endotracheal intubation <br/ ><br>T15: 15 minutes after endotracheal intubation <br/ ><br>Thereafter, every 15 minutes till the end of surgery. Upto 24 hrs

Secondary Outcome Measures

Name	Time	Method
1 Change in diastolic blood pressure (DBP) and mean arterial pressure (MAP) <br/ ><br>2 Side effects of the two study drugsTimepoint: Tb: Baseline in OT <br/ ><br>Td: After test drug administration over 10 minutes <br/ ><br>Tp: After propofol administration <br/ ><br>Tv: 3 minutes after vecuronium administration <br/ ><br>T0: At the time of intubation <br/ ><br>T1: 1 minute after endotracheal intubation <br/ ><br>T3: 3 minutes after endotracheal intubation <br/ ><br>T5: 5 minutes after endotracheal intubation <br/ ><br>T10: 10 minutes after endotracheal intubation <br/ ><br>T15: 15 minutes after endotracheal intubation <br/ ><br>Thereafter, every 15 minutes till the end of surgery. Upto 24 hrs