Effects of Yoga on Sodium-induced Pressor Responses in African American Adults

Not Applicable

Completed

• Conditions: Blood Pressure
• Interventions: Behavioral: Waitlist control; Behavioral: Yoga

• Registration Number: NCT05353270
• Lead Sponsor: Texas State University

Brief Summary

This investigation aims to determine the effects of a 4-week yoga intervention on sodium-induced pressor and endothelial function responses as well as markers of renal sodium handling in African American adults.

Detailed Description

Not available

Study Timeline

• Study Start: 2021-09-01
• Study First Submitted: 2022-04-25
• Study First Submitted QC: 2022-04-25
• Study First Posted: 2022-04-29
• Primary Completion: 2022-07-01
• Study Completion: 2022-07-01
• Status Verified: 2024-04
• Last Update Submitted: 2024-04-09
• Last Update Posted: 2024-04-10

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 15

Inclusion Criteria

• African American
• Adults ages 18-60 years

Exclusion Criteria

• pregnancy or within 60 days postpartum
• having taken blood pressure (including diuretics beta-blockers, ACE inhibitors, angiotensin receptor blockers, and calcium channel blockers) or statin medications within the past 3 months (statins have been demonstrated to reduce oxidative stress which could impact flow-mediated dilation);
• infection (viral or other) within the past 4 weeks;
• having adrenal or endocrine tumors (these could impact BP);
• renal disease defined as a glomerular filtration rate (GFR) of less than 60 (creatinine will be tested at initial screening and GFR will be calculated);
• prior myocardial infarction; vii) known coronary heart disease;
• personal history of stroke;
• heart failure;
• cardiac arrhythmias;
• chronic obstructive pulmonary disease;
• recent chest pain or dyspnea;
• orthopedic limitations that preclude the execution of yoga postures;
• current insulin dependence;
• currently taking steroid medications;
• currently undergoing chemotherapy or radiation;
• having practiced yoga or yogic breathing techniques at least once weekly consistently within the past 3 months;
• heat intolerance or electrolyte imbalances (hypo- or hyper-natremia or hypo- or hyper-kalemia).

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Waitlist control	Waitlist control	Waitlisted participants will maintain their normal diet and exercise patterns for 4 weeks prior to rerandomization to the yoga group.
Yoga	Yoga	Yoga sessions (35 minutes each) will be performed 5 times weekly for 4 weeks.

Primary Outcome Measures

Name	Time	Method
Change in arterial stiffness from low- to high-sodium dietary conditions.	Measurements will be completed after 3 days of low- and 3 days of high-sodium intake at baseline and at week 4.	Cardio-ankle vascular index will be measured after 3 days of low- and 3 days of high-sodium intake.
Change in endothelial function from low- to high-sodium dietary conditions.	Measurements will be completed after 3 days of low- and 3 days of high-sodium intake at baseline and at week 4.	Flow-mediated dilation will be measured via ultrasound imaging of the upper arm after 3 days of low- and 3 days of high- sodium dietary conditions.
Change in blood pressure from low- to high-sodium dietary conditions	Measurements will be completed after 3 days of low and 3 days of high sodium intake at baseline and after 4 weeks for both conditions.	Blood pressure will be measured after 3 days of very low sodium and 3 days of high sodium intake.

Secondary Outcome Measures

Name	Time	Method
Change in urinary sodium excretion from low- to high-sodium dietary conditions.	Measurements will be completed after 3 days of low- and 3 days of high-sodium intake at baseline and at week 4.	24-hour urine collection will be completed after 3 days of low- and after 3 days of high-sodium dietary conditions.

Trial Locations

Locations (1)

Cardiovascular Physiology Laboratory-Texas State University; 🇺🇸 San Marcos, Texas, United States