Host Response to Urinary Tract Infection in Women

Completed

Brief Summary: This study is being done to identify those elements of the immune response that may predispose a woman to recurrent urinary tract infection. We suspect that lesser effectiveness of certain components of the host response will lead to recurrent urinary tract infection. We will also evaluate the role that the bladder reservoir may play in recurrent urinary tract infection.

Detailed Description: Procedures subjects will undergo once they have read and signed the consent are:

Questions about their medical and sexual history and current symptoms of urinary tract infection. They will be asked to provide a clean catch urine sample. We will collect periurethral, vaginal and rectal swabs. Blood will collected. They will be given a diary to take home and record all episodes of sexual intercourse, contraceptive use, vaginal and urinary symptoms and medication use.

They will be given standard treatment for the current urinary tract infection. Follow-up visits will be scheduled 2 weeks,one month,two month and three month after initial visit.

Recruitment & Eligibility

Inclusion Criteria

Exclusion Criteria

Not pregnant or planning pregnancy in next 3 months
No chronic illness requiring medical supervision (e.g. diabetes mellitus)
No known anatomic or functional abnormalities of the urinary tract
No signs or symptoms suggestive of pyelonephritis (flank pain or tenderness, temperature over 100 degrees F, nausea or vomiting)

Primary Outcome Measures

Name	Time	Method
Determine elements of the immune response that may predispose a woman to recurrent urinary tract infection	2017

Secondary Outcome Measures

Name	Time	Method

Locations (1): University of Washington/Hall Health Primary Care Center
🇺🇸
Seattle, Washington, United States

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