Host Response to Urinary Tract Infection in Women
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 326
- 试验地点
- 1
- 主要终点
- Determine elements of the immune response that may predispose a woman to recurrent urinary tract infection
研究概览
简要总结
This study is being done to identify those elements of the immune response that may predispose a woman to recurrent urinary tract infection. We suspect that lesser effectiveness of certain components of the host response will lead to recurrent urinary tract infection. We will also evaluate the role that the bladder reservoir may play in recurrent urinary tract infection.
详细描述
Procedures subjects will undergo once they have read and signed the consent are:
Questions about their medical and sexual history and current symptoms of urinary tract infection. They will be asked to provide a clean catch urine sample. We will collect periurethral, vaginal and rectal swabs. Blood will collected. They will be given a diary to take home and record all episodes of sexual intercourse, contraceptive use, vaginal and urinary symptoms and medication use.
They will be given standard treatment for the current urinary tract infection. Follow-up visits will be scheduled 2 weeks,one month,two month and three month after initial visit.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 49 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Age 18-49 years
- •Able to provide written informed consent
- •diagnosis of acute cystitis with symptoms for fewer than 7 days
排除标准
- •Not pregnant or planning pregnancy in next 3 months
- •No chronic illness requiring medical supervision (e.g. diabetes mellitus)
- •No known anatomic or functional abnormalities of the urinary tract
- •No signs or symptoms suggestive of pyelonephritis (flank pain or tenderness, temperature over 100 degrees F, nausea or vomiting)
结局指标
主要结局
Determine elements of the immune response that may predispose a woman to recurrent urinary tract infection
时间窗: 2017
次要结局
未报告次要终点
研究者
Ann Stapleton
Professor
University of Washington